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Design Innovation

Development and Performance of a Controllable Autoloading Needle-Free Jet Injector

[+] Author and Article Information
Brian D. Hemond1

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139bhemond@mit.edu

Andrew Taberner, Cathy Hogan, Bryan Crane, Ian W. Hunter

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139

1

Corresponding author.

J. Med. Devices 5(1), 015001 (Feb 03, 2011) (7 pages) doi:10.1115/1.4003330 History: Received March 08, 2010; Revised November 14, 2010; Published February 03, 2011; Online February 03, 2011

A jet injector platform technology that provides improved performance over existing jet injectors through the use of a controllable linear Lorentz-force actuator and software-based control system has been developed. Injectors designed on this platform are capable of delivering injections using arbitrary pressure pulse shaping. Pulse shaping has been shown to allow a wide degree of control over the depth to which the injection is delivered. A software-based injector control system improves repeatability and allows for automatic reloading of the injector, a task that would be difficult to implement using existing jet injector platforms. A design for a prototype autoloading controllable jet injector (cJI) based on this platform is detailed. The injection capability of this cJI was evaluated both in-vitro and in-vivo using a tissue analog, excised porcine tissue, and ovine tissue. An analysis of the cJI’s performance indicates that this design is capable of delivering a controllable volume of fluid to a controllable depth based entirely on the parameter’s input into the control software.

Copyright © 2011 by American Society of Mechanical Engineers
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References

Figures

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Figure 1

A photograph of the completed cJI instrument

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Figure 2

A computer-aided design (CAD) model of the injection cylinder

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Figure 3

Illustration of the autoloader and its connection to the injection cylinder

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Figure 4

Schematic of the control system for the cJI when injecting

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Figure 5

Sensor data captured from the cJI driven with a step

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Figure 6

The modeled and recorded pressure step response of the cJI instrument

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Figure 7

Schematic of the cJI control system used during autoloading and stabilization

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Figure 8

A sequence of video frames demonstrating the progression of a 5% Bromocresol Green solution into acrylamide gel. The width of each frame is approximately 25 mm. Frame spacing is approximately 5 ms. A pressure pulse of 50 MPa for 5 ms followed by 20 MPa for 45 ms was used for this injection; the total delivery volume being approximately 80 μl.

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Figure 9

A plot of injection penetration depth versus injection pressure for two different concentrations of acrylamide gel

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Figure 10

A photograph of two injections into acrylamide gel. The gel on the left was injected with a peak pressure of 25 MPa while the gel on the right was injected with a peak of 60 MPa. The follow-through pressure for both injections was 8 MPa, and the volume of fluid delivered in each injection was approximately 86 μl.

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Figure 11

A plot of the injection cylinder pressure for five of the nine injections into 10% acrylamide gel used in the depth control test

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Figure 12

Delivery volume and injection depth as functions of the period of the follow-through phase of the injection. Peak injection pressure was held constant at 36.6 MPa+/−0.77 MPa.

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Figure 13

A plot of the injection cylinder pressure during the delivery volume test. The peak and follow-through pressures in each run remain the same while the length of the follow-through phase varies.

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Figure 14

Side view of sections of porcine tissue post-injection. The section on the left was injected with a peak pressure of 37 MPa while the section on the right was injected with a peak pressure of 77 MPa, at constant follow-through pressure and volume.

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Figure 15

A plot of injection depth and injection volume against injection pressure

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