Design Innovation

Development and Performance of a Controllable Autoloading Needle-Free Jet Injector

[+] Author and Article Information
Brian D. Hemond1

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139bhemond@mit.edu

Andrew Taberner, Cathy Hogan, Bryan Crane, Ian W. Hunter

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139


Corresponding author.

J. Med. Devices 5(1), 015001 (Feb 03, 2011) (7 pages) doi:10.1115/1.4003330 History: Received March 08, 2010; Revised November 14, 2010; Published February 03, 2011; Online February 03, 2011

A jet injector platform technology that provides improved performance over existing jet injectors through the use of a controllable linear Lorentz-force actuator and software-based control system has been developed. Injectors designed on this platform are capable of delivering injections using arbitrary pressure pulse shaping. Pulse shaping has been shown to allow a wide degree of control over the depth to which the injection is delivered. A software-based injector control system improves repeatability and allows for automatic reloading of the injector, a task that would be difficult to implement using existing jet injector platforms. A design for a prototype autoloading controllable jet injector (cJI) based on this platform is detailed. The injection capability of this cJI was evaluated both in-vitro and in-vivo using a tissue analog, excised porcine tissue, and ovine tissue. An analysis of the cJI’s performance indicates that this design is capable of delivering a controllable volume of fluid to a controllable depth based entirely on the parameter’s input into the control software.

Copyright © 2011 by American Society of Mechanical Engineers
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Figure 1

A photograph of the completed cJI instrument

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Figure 2

A computer-aided design (CAD) model of the injection cylinder

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Figure 3

Illustration of the autoloader and its connection to the injection cylinder

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Figure 4

Schematic of the control system for the cJI when injecting

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Figure 5

Sensor data captured from the cJI driven with a step

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Figure 6

The modeled and recorded pressure step response of the cJI instrument

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Figure 7

Schematic of the cJI control system used during autoloading and stabilization

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Figure 8

A sequence of video frames demonstrating the progression of a 5% Bromocresol Green solution into acrylamide gel. The width of each frame is approximately 25 mm. Frame spacing is approximately 5 ms. A pressure pulse of 50 MPa for 5 ms followed by 20 MPa for 45 ms was used for this injection; the total delivery volume being approximately 80 μl.

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Figure 9

A plot of injection penetration depth versus injection pressure for two different concentrations of acrylamide gel

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Figure 10

A photograph of two injections into acrylamide gel. The gel on the left was injected with a peak pressure of 25 MPa while the gel on the right was injected with a peak of 60 MPa. The follow-through pressure for both injections was 8 MPa, and the volume of fluid delivered in each injection was approximately 86 μl.

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Figure 11

A plot of the injection cylinder pressure for five of the nine injections into 10% acrylamide gel used in the depth control test

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Figure 12

Delivery volume and injection depth as functions of the period of the follow-through phase of the injection. Peak injection pressure was held constant at 36.6 MPa+/−0.77 MPa.

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Figure 13

A plot of the injection cylinder pressure during the delivery volume test. The peak and follow-through pressures in each run remain the same while the length of the follow-through phase varies.

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Figure 14

Side view of sections of porcine tissue post-injection. The section on the left was injected with a peak pressure of 37 MPa while the section on the right was injected with a peak pressure of 77 MPa, at constant follow-through pressure and volume.

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Figure 15

A plot of injection depth and injection volume against injection pressure




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