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Design Innovation Papers

Thermochemical Ablation: A Device for a Novel Interventional Concept

[+] Author and Article Information
Matthew G. Geeslin1

 University of Minnesota Medical School,  University of Minnesota, Minneapolis, MN 55455GEESL001@UMN.EDU

Erik N. Cressman

Department of Radiology,  University of Minnesota, Minneapolis, MN 55455

1

Corresponding author.

J. Med. Devices 6(1), 015001 (Mar 13, 2012) (5 pages) doi:10.1115/1.4005785 History: Received May 27, 2011; Revised November 07, 2011; Published March 12, 2012; Online March 13, 2012

Solid focal and oligometastatic malignancies are appropriate targets for minimally invasive ablative procedures. Thermochemical ablation is an experimental minimally invasive procedure, which exploits certain features of current thermal and chemical tumor ablation therapies. Engineering principles have been used to design a device, which has been research-proven-capable of coagulating tissue through the combination of a thermal and chemical insult. This interventional device completes this assignment by separately guiding the flow of chemical reagents, drawn from auxiliary systems, to a point at the distal tip of an assembled apparatus. At this position, the respective flow-streams converge and undergo an exothermic reaction to produce a heated, hyperosmolar solute, which serves to ablate the targeted tissue. Ex and in vivo studies have confirmed the utility of this device and the physiologic toleration of this interventional concept.

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Copyright © 2012 by American Society of Mechanical Engineers
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Figures

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Figure 1

Overall view of the thermochemical ablation device displaying its key operational components

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Figure 2

Vector-based drawing of the TCA device tip (left) and schematic flow diagram of the distal portion of the TCA device (right)

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Figure 3

Schematic of reagent flow throughout the entire device as well as labeled device components through which the reagents travel

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Figure 4

Photographs of the assembled (top) and disassembled (bottom) components of the thermochemical ablation device

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Figure 5

Ultrasound image of the TCA device tip and a temperature probe situated at a distance of approximately 6 mm

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Figure 6

Chart displaying the average change in temperature for a given injection volume and reagent concentration of sodium hydroxide and acetic acid. Measurements were obtained with a temperature probe inserted at a distance of 5 mm from the device tip.

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Figure 7

Formalin-fixed, fast-frozen, and H&E stained histological sections of thermochemically ablated porcine liver. (a) 2 mm formalin-fixed section, (b) 2 mm fast-frozen tissue section, and (c) H&E stained specimen. These images were obtained using sodium hydroxide and acetic acid at 10 M concentrations.

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Figure 8

Osirix image slice (left) and three-dimensional reconstruction of a contrast enhanced thermochemical liver ablation (right)

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