In this work, the deployment of a self-expanding stent in a stenosed artery was evaluated through finite element analysis. The three-layered structure of the artery and their material properties were measured and implemented in our computational models. The instant outcomes, including lumen gain, tissue prolapse, and stress distribution, were quantified, and the effect of plaque calcification was evaluated. Results showed that the peak wall stress occurred on the media layer regardless of plaque calcification. The calcified plaque mitigated the tissue prolapse and arterial wall stresses in general, compared with the soft plaque. However, the lesion calcification led to a more severe residual stenosis, dogboning effect, and corresponding edge stress concentrations after stenting, which requires pre- and/or post-surgical management.