Research Papers

Mixing Efficiency of Red Blood Cells With Magnetic Microspheres for a Hybrid Separation System

[+] Author and Article Information
Yousef Haik

Center of Research Excellence in Nanobiosciences, University of North Carolina-Greensboro, Greensboro, NC 27402;Department of Mechanical Engineering, United Arab Emirates University, P.O. Box 17555, Al Ain, United Arab Emirates

Sridhar Kanuri

Center for Nanomagnetics and Biotechnology, Florida State University, Tallahassee, FL 32310

J. Med. Devices 2(3), 031006 (Sep 16, 2008) (8 pages) doi:10.1115/1.2975963 History: Received March 05, 2006; Revised July 01, 2008; Published September 16, 2008

The mixing efficiency of red blood cells and magnetic microspheres with red blood cell tagging ability is investigated using color particle image velocimetry. A hybrid separation system that utilizes centrifugation and magnetic separation is described. Magnetic microspheres are utilized to isolate the red cells from the buffy coat on a continuous basis. The effectiveness of red blood cell separation from the buffy coat in the hybrid system was improved over conventional centrifugal separation methods.

Copyright © 2008 by American Society of Mechanical Engineers
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Figure 1

Continuous magnetic separation system

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Figure 2

Actual experimental setup of the system

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Figure 3

Albumin magnetic microspheres

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Figure 9

Shear stress for both the walls at inlet 1

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Figure 10

Shear stress for both the walls at inlet 2

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Figure 11

Shear stress for both the walls at outlet. (a) Plot of shear at t=0 s, (b) plot of shear at t=6/7 s, (c) plot of shear at t=9/7 s, (d) plot of shear at t=12/7 s, (e) plot of shear at t=15/7 s, (f) plot of shear at t=18/7 s, (g) plot of shear at t=21/7 s, and (h) plot of shear at t=0 s.

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Figure 12

Time sequential plots of shear stress at center of T-chamber

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Figure 13

Hematocrit versus absorbance curve

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Figure 8

T-chamber with inlet, outlet, and center regions indicated

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Figure 7

Strouhal number versus Reynolds number

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Figure 6

Velocity vector profile of flow at center of T-chamber

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Figure 5

Formation of vortices at the center of the T-chamber. The time of exposure was set to 500 ms. (a) Collision of two liquids at the center of cuvette, (b) formation of vortex, (c) movement of vortex, (d) movement of vortex, (e) movement of vortex, (f) vortex starts to shed, and (g) vortex sheds and formation of new vortex can also be seen.

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Figure 4

Oscillation of fluid collision at the center of T-chamber




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