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2010 Design of Medical Devices Conference Abstracts

Toward the Development of Novel Nitric Oxide Donating Polymeric Materials to Improve the Biocompatibility of Implanted Devices OPEN ACCESS

[+] Author and Article Information
Elizabeth Moore, Megan C. Frost

Michigan Technological University

J. Med. Devices 4(2), 027532 (Aug 11, 2010) (1 page) doi:10.1115/1.3443738 History: Published August 11, 2010

Abstract

Previous studies have shown that many S-nitrosothiols (RSNOs) rapidly degrade, with half-lives from minutes to seconds in aqueous solution [1]. The research presented in this paper presents data that the RSNO 1,3-benzenedinitrosothiol has been relatively stable for over 1 year. This RSNO still releases nitric oxide (NO) when subjected to ultraviolet light and has the same characteristic absorbance peak as a freshly made RSNO. Developing this stable RSNO potentially provides a venue for further investigation into using this NO donor to improve the biocompatibility of implanted optical sensors.

Copyright © 2010 by American Society of Mechanical Engineers
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