2010 Design of Medical Devices Conference Abstracts

Linear Control of Neuronal Spike Timing Using Phase Response Curves PUBLIC ACCESS

[+] Author and Article Information
Tyler Stigen

University of Minnesota

P. Danzl, J Moehlis

University of California–Santa Barbara

T. I. Netoff

Univeristy of Minnesota

J. Med. Devices 4(2), 027533 (Aug 11, 2010) (1 page) doi:10.1115/1.3443740 History: Published August 11, 2010


We propose a simple, robust, and linear method to control the spike timing of a periodically firing neuron. The control scheme uses the neuron’s phase response curve to identify an area of optimal sensitivity for the chosen stimulation parameters. The spike advance as a function of current pulse amplitude is characterized at the optimal phase, and a linear least-squares regression is fit to the data. The inverted regression is used as the control function for this method. The efficacy of this method is demonstrated through numerical simulations of a Hodgkin–Huxley style neuron model as well as in real neurons from rat hippocampal slice preparations. The study shows a proof of concept for the application of a linear control scheme to control neuron spike timing in vitro. This study was done on an individual cell level, but translation to a tissue or network level is possible. Control schemes of this type could be implemented in a closed loop implantable device to treat neuromotor disorders involving pathologically neuronal activity such as epilepsy or Parkinson’s disease.

Copyright © 2010 by American Society of Mechanical Engineers
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