Technical Briefs

A Model of Drug Deposition Within Artery Walls

[+] Author and Article Information
John Gorman

University of St. Thomas,
School of Engineering

Ephraim Sparrow

University of Minnesota,
Department of Mechanical Engineering

Rob Kohler

Cardiovascular Systems, Inc.

Manuscript received March 15, 2013; final manuscript received April 24, 2013; published online May 30, 2013. Editor: Arthur G. Erdman.

J. Med. Devices 7(2), 020902 (May 30, 2013) (2 pages) Paper No: MED-13-1028; doi: 10.1115/1.4024321 History: Received March 15, 2013; Revised April 24, 2013

First Page Preview

View Large
First page PDF preview
Copyright © 2013 by ASME
Your Session has timed out. Please sign back in to continue.


Lovich, M. A., Creel, C., Hong, K., Hwang, C. W., and Edelman, E. R., 2001, “Carrier Proteins Determine Local Pharmacokinetics and Arterial Distribution of Paclitaxel”, J. Pharma. Sci., 90, pp. 1324–1335. [CrossRef]
Abraham, J. P., Sparrow, E. M., Gorman, J. M.Stark, J. R., and Kohler, R. E., 2013, “A Mass Transfer Model of Temporal Drug Deposition in Artery Walls,” Int. J. Heat Mass Transfer, 58, pp. 632–638. [CrossRef]


Grahic Jump Location
Fig. 1

Normalized drug concentration within artery wall (Ct/Cf). A comparison of the present model with estimates taken from [1] (adapted from [2]).

Grahic Jump Location
Fig. 2

Distribution of normalized concentration (Ct/Cf) for the lower carrier fluid viscosity and a two-minute application (adapted from [2]).

Grahic Jump Location
Fig. 3

Variation of normalized drug concentration divided by the therapy duration (adapted from [2]).



Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In