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Differentiation of Bilateral Neuromodulation for Bladder Control Using a Preclinical Model

[+] Author and Article Information
Xin Su, Dwight E. Nelson

Neuromodulation Research

Angela Nickles

Physiology Research Laboratory,
Medtronic, Inc

Manuscript received March 15, 2013; final manuscript received April 24, 2013; published online June 5, 2013. Editor: Arthur G. Erdman.

J. Med. Devices 7(2), 020909 (Jun 05, 2013) (3 pages) Paper No: MED-13-1043; doi: 10.1115/1.4024316 History: Received March 15, 2013; Revised April 25, 2013

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References

Tanagho, E. A., Schmidt, R. A., 1988, “Electrical Stimulation in the Clinical Management of the Neurogenic Bladder,” J. Urol., 140, pp. 1331–1339. [PubMed]
Scheepens, W. A., de Bie, R. A., WeilEH, van Kerrebroeck, P. E., 2002, “Unilateral Versus Bilateral Sacral Neuromodulation in Patients With Chronic Voiding Dysfunction,” J. Urol., 168, pp. 2046–2050. [CrossRef] [PubMed]
Seif, C., Eckermann, J., Bross, S., Portillo, F. J. M., Junemann, K., Braun, P., 2004, “Findings With Bilateral Sacral Neruostimulation: Sixty-Two PNE-Tests in Patients With Neurogenic and Idiopathic Bladder Dysfunctions,” Neruomodulation, 7, pp. 141–145. [CrossRef]
Hohenfellner, M., Schultz-Lampel, D., Dahms, S., Matzel, K., Thüroff, J. W., 1998, “Bilateral Chronic Sacral Neuromodulation for Treatment of Lower Urinary Tract Dysfunction,” J. Urol., 160, pp. 821–824. [CrossRef] [PubMed]
Steinberg, A. C., Oyama, I. A., Whitmore, K. E., 2007, “Bilateral S3 Stimulator in Patients With Interstitial Cystitis,” Urology, 69, pp. 441–443. [CrossRef] [PubMed]
Schultz-Lampel, D., Jiang, C., Lindström, S., Thüroff, W., 1998, “Neurophysiologicsche Effeckte Unilteraler und Bilateraler Sakraler Neuromodulation,” Akt Urol., 29, pp. 354–360. [CrossRef]
Schultz-Lampel, D., Jiang, C., Lindström, S., Thüroff, J. W., 1998, “Experimental Results on Mechanisms of Action of Electrical Neuromodulation in Chronic Urinary Retention, World J Urol., 16, pp. 301–304. [CrossRef] [PubMed]
Kaufmann, S., Naumann, C. M., Hamann, M. F., Seif, C., Braun, P. M., Jünemann, K. P., van der Horst, C., 2009, “Unilateral vs Bilateral Sacral Neuromodulation in Pigs With Formalin-Induced Detrusor Hyperactivity,” BJU Int., 103, pp. 260–263. [CrossRef] [PubMed]
Su, X., Nickles, A., Nelson, D. E., “Neuromodulation in a Rat Model of the Bladder Micturition Reflex,” Am J Physiol Renal Physiol., 302, pp. F477–F486. [CrossRef] [PubMed]
Diokno, A. C., Davis, R., Lapides, J., 1973, “The Effect of Pelvic Nerve Stimulation on Detrusor Contraction,” Invest Urol., 11:178–181. [PubMed]

Figures

Grahic Jump Location
Fig. 1

Typical experimental records showing the bladder rhythmic contraction to bilateral phase match stimulation (A), bilateral phase mismatch stimulation (B) and sequential, alternative 5-min stimulation of left and right spinal nerve (C) at motor threshold intensity (10 Hz, pulse width 0.1 ms). Horizontal bars indicate 10-min duration of spinal nerve stimulation. Shown on the left is schematic drawing of stimulation pulses.

Grahic Jump Location
Fig. 2

Effects of spinal nerve stimulation (bilateral phase match stimulation, bilateral phase mismatch stimulation and sequential, alternative 5-min stimulation of left and right spinal nerve) on the frequency of the bladder rhythmic contraction during 10-min stimulation (A) and 20-min post stimulation (B). Responses are represented as a percentage of control (% control). *p < 0.05, Student's t-test.

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