Technical Briefs

Differentiation of Bilateral Neuromodulation for Bladder Control Using a Preclinical Model

[+] Author and Article Information
Xin Su, Dwight E. Nelson

Neuromodulation Research

Angela Nickles

Physiology Research Laboratory,
Medtronic, Inc

Manuscript received March 15, 2013; final manuscript received April 24, 2013; published online June 5, 2013. Editor: Arthur G. Erdman.

J. Med. Devices 7(2), 020909 (Jun 05, 2013) (3 pages) Paper No: MED-13-1043; doi: 10.1115/1.4024316 History: Received March 15, 2013; Revised April 25, 2013

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Grahic Jump Location
Fig. 1

Typical experimental records showing the bladder rhythmic contraction to bilateral phase match stimulation (A), bilateral phase mismatch stimulation (B) and sequential, alternative 5-min stimulation of left and right spinal nerve (C) at motor threshold intensity (10 Hz, pulse width 0.1 ms). Horizontal bars indicate 10-min duration of spinal nerve stimulation. Shown on the left is schematic drawing of stimulation pulses.

Grahic Jump Location
Fig. 2

Effects of spinal nerve stimulation (bilateral phase match stimulation, bilateral phase mismatch stimulation and sequential, alternative 5-min stimulation of left and right spinal nerve) on the frequency of the bladder rhythmic contraction during 10-min stimulation (A) and 20-min post stimulation (B). Responses are represented as a percentage of control (% control). *p < 0.05, Student's t-test.



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