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Technical Briefs

Rapid Prototyping of Flexible Structures for Tissue Engineered Ear Reconstruction

[+] Author and Article Information
Anya Kimura

Department of Surgery,
Massachusetts General Hospital,
Boston, MA

Nicholas Roscioli

Kensey Nash Corporation,
Exton, PA

Cathryn A. Sundback

Department of Surgery,
Massachusetts General Hospital,
Boston, MA;
Harvard Medical School,
Boston, MA

Manuscript received March 15, 2013; final manuscript received April 25, 2013; published online June 11, 2013. Editor: Arthur G. Erdman.

J. Med. Devices 7(2), 020942 (Jun 11, 2013) (2 pages) Paper No: MED-13-1049; doi: 10.1115/1.4024332 History: Received March 15, 2013; Revised April 25, 2013

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References

Vacanti, C. A., Cima, L. G., Ratkowski, D., Upton, J., Vacanti, J. P., 1991, “Tissue Engineered Growth of New Cartilage in the Shape of a Human Ear Using Synthetic Polymers Seeded With Chondrocytes,” Mater. Res. Soc. Symp. Proc., 252, pp. 367–374. [CrossRef]
Bichara, D. A., O'Sullivan, N. A., Pomerantseva, I., Zhao, X., Sundback, C. A., Vacanti, J. P., and Randolph, M. A., 2012, “The Tissue-Engineered Auricle: Past, Present, and Future,” Tissue Eng. Part B Rev., 18(1), pp. 51–61. [CrossRef] [PubMed]
Zhou, L., Pomerantseva, I., Bassett, E. K., Bowley, C. M., Zhao, X., Bichara, D. A., Kulig, K. M., Vacanti, J. P., Randolph, M. A., and Sundback, C. A., 2011, “Engineering Ear Constructs With a Composite Scaffold to Maintain Dimensions,” Tissue Eng. Part A, 17(11–12), pp. 1573–1581. [CrossRef] [PubMed]
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Bertol, L. S., Junior, W. K., da Silva, F. P., and Aumund-Kopp, C., 2010, “Medical Design: Direct Metal Laser Sintering of Ti-6Al-4V,” Mater. Design, 31(8), pp. 3982–3988. [CrossRef]
Murr, L. E., Quinones, S. A., Gaytan, S. M., Lopez, M. I., Rodela, A., Martinez, E. Y., Hernandez, D. H., Martinez, E., Medina, F., and Wicker, R. B., 2009, “Microstructure and Mechanical Behavior of Ti-6Al-4B Produced by Rapid-Layer Manufacturing, for Biomedical Applications,” J. Mech. Behav. Biomed. Mater., 2(1), p. 20–32. [CrossRef]

Figures

Grahic Jump Location
Fig. 1

Metal ear frameworks built using rapid prototyping processes. (A) CAD model of the desired ear geometry (Scale bar = 5 mm). (B) Initial structure produced using DMLS. The size and geometry of the part prevents removal of the support material without damage. (C) Structure produced using EBM. Although the size is acceptable, the framework is brittle and therefore unsuitable for use in the tissue engineered ear (D) Structure produced using DMLS with a smaller powder diameter. Support material was removed cleanly and without damage, and the resulting structure was capable of bending. (E) Composite ear-shaped scaffold made with a successful DMLS framework embedded into porous collagen.

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