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Technical Briefs

Surface Modification of Polyimide Thin Films for Peripheral Invasive Neural Interfaces

[+] Author and Article Information
M. Righi

e-mail: m.righi@sssup.it

S. Bossi

Senior Post-doctoral Fellow
e-mail: s.bossi@sssup.it
The BioRobotics Institute Scuola Superiore Sant'Anna,
Viale Rinaldo Piaggio 34,
56025 Potedera (PI), Italy

GL. Puleo

Senior Post-doctoral Fellow
Center for Micro-BioRobotics,
Italian Institute of Technology (IIT)
c/o Scuola Superiore Sant'Anna,
Viale Rinaldo Piaggio 34,
56025 Potedera (PI), Italy
e-mail: GianLuigi.Puleo@iit.it

G. Giudetti

Senior Post-doctoral Fellow
The BioRobotics Institute Scuola Superiore Sant'Anna,
Viale Rinaldo Piaggio 34,
56025 Potedera (PI), Italy;
Center for Micro-BioRobotics,
Italian Institute of Technology (IIT)
c/o Scuola Superiore Sant'Anna,
Viale Rinaldo Piaggio 34,
56025 Potedera (PI), Italy
e-mail: guido.giudetti@sssup.it

P. Wieringa

The BioRobotics Institute Scuola Superiore Sant'Anna,
Viale Rinaldo Piaggio 34,
56025 Potedera (PI), Italy;
Center for Micro-BioRobotics,
Italian Institute of Technology (IIT)
c/o Scuola Superiore Sant'Anna,
Viale Rinaldo Piaggio 34,
56025 Potedera (PI), Italy;
MIRA Institute for Biomedical Technology and Technical Medicine,
Department of Tissue Regeneration,
University of Twente,
The Netherlands
e-mail: p.wieringa@sssup.it

A. Cutrone

The BioRobotics Institute Scuola Superiore Sant'Anna,
Viale Rinaldo Piaggio 34,
56025 Potedera (PI), Italy
e-mail: a.cutrone@sssup.it

S. Micera

Professor Neural Engineering Area
The BioRobotics Institute Scuola Superiore Sant'Anna,
Viale Rinaldo Piaggio 34,
56025 Potedera (PI), Italy;
Translational Neural Engineering Laboratory,
Center for Neuroprosthetics and Institute of Bioengineering (IBI)-School of Engineering,
cole Polytechnique Fdrale de Lausanne (EPFL),
Lausanne, Switzerland
e-mail: s.micera@sssup.it

Manuscript received March 13, 2013; final manuscript received April 30, 2013; published online June 17, 2013. Editor: Gerald E. Miller.

J. Med. Devices 7(2), 020937 (Jun 17, 2013) (3 pages) Paper No: MED-13-1025; doi: 10.1115/1.4024378 History: Received March 13, 2013; Revised April 30, 2013

Despite recognized as one key component for establishing a functional electrical connection with nerves, neural invasive peripheral interfaces are still not optimal for long-term applications in humans. An improvement in the field of biocompatible and non-toxic materials is necessary to overcome the issues of interface/tissue mismatch and physiological reactions. The present work aimed to study, implement and characterize a novel approach to modify the surface of neural mi-crolectrodes basedon polyimide thin films. The purpose was to improve biocompatibility and to promote neuronal migration, growth and differentiation by increasing the surface roughness and endowing the surface with structure-reactivity for thiol-containing amino acids or peptides. L-Cysteine-Rhodamine B, used as a model biomolecule, was successfully grafted on samples surface via the introduction of cross-linkable vinyl groups on polyimide foils. Preliminary in vitro biological analysis allowed to evaluate the tendency of PC12 cells to adhere and to proliferate.

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References

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Van Vlierberghe, S., Sirova, M., Rossmann, P., Thielecke, H., Boterberg, V., Rihova, B., Schacht, E., and Dubruel, P., 2010. “Surface Nodification of Polyimide Sheets for Regenerative Medicine Applications”. Biomacromolecules, 11(10), pp. 273–279. [CrossRef]
Ciofani, G., Genchi, G. G., and Mattoli, V., 2012. “Zno Nanowire Arrays as Substrates for Cell Proliferation and Differentiation”, Materials Science and Engineering: C, 32(2), pp. 341–347. [CrossRef]

Figures

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Fig. 1

AFM3D topography of PI

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Fig. 2

AFM 3D topography of PI*

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Fig. 3

Cell attachment evaluation: visible light (left) and UV light w/DAPI filter (right)

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