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Technical Briefs

Irreversible Electroporation of Cardiovascular Cells and Tissues

[+] Author and Article Information
Chunlan Jiang

Department of Mechanical Engineering,
University of Minnesota

Ryan Goff

Department of Biomedical Engineering,
University of Minnesota;
Department of Surgery,
University of Minnesota

Pong Patana-anake

Department of Mechanical Engineering,
University of Minnesota

Paul A. Iaizzo

Department of Mechanical Engineering,
University of Minnesota;
Department of Biomedical Engineering,
University of Minnesota;
Department of Surgery,
University of Minnesota;
Institute for Engineering in Medicine,
University of Minnesota

John Bischof

Department of Mechanical Engineering,
University of Minnesota;
Department of Biomedical Engineering,
University of Minnesota;
Institute for Engineering in Medicine,
University of Minnesota

Manuscript received March 15, 2013; final manuscript received April 26, 2013; published online July 3, 2013. Assoc. Editor: Arthur G. Erdman.

J. Med. Devices 7(3), 030903 (Jul 03, 2013) (3 pages) Paper No: MED-13-1034; doi: 10.1115/1.4024510 History: Received March 15, 2013; Revised April 26, 2013

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References

Heidenreich, P. A., et al. ., 2011, “Forecasting the Future of Cardiovascular Disease in the United States, a Policy Statement from the American Heart Association,” Circulation, 123(8), pp. 933–944. [CrossRef] [PubMed]
Calkins, H., et al. ., 1999, “Catheter Ablation of Accessory Pathways, Atrioventricular Nodal Reentrant Tachycardia, and the Atrioventricular Junction Final Results of a Prospective, Multicenter Clinical Trial,” Circulation, 99(2), pp. 262–270. [CrossRef] [PubMed]
Weaver, J., 2002, “Electroporation of Cells and Tissues,” Plasma Science, IEEE Transactions, 28(1), pp. 23–33.
Claycomb, W. C., et al. ., 1998, “HL-1 Cells: A Cardiac Muscle Cell Line That Contracts and Retains Phenotypic Characteristics of the Adult Cardiomyocyte,” PNAS, 95(6), pp. 2979–2984. [CrossRef] [PubMed]
Jiang, C., et al. ., 2012, “An in vitro Study on Adjuvant Enhanced Irreversible Electroporation,” presented at the Summer Bioengineering Conference, Farjardo, Puerto Rico, USA.

Figures

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Fig. 1

Electroporation experiment setups for: (a) cell suspensions within a cuvette placed in an external electrical field, and (b) treatment of a vascular tissue with ring-needle electrode configuration

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Fig. 2

Viability results of the HL-1 cell line after electroporation with 200 V, 50 μs and varied number of pulses. (N = 4, error bars represent standard deviations.)

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Fig. 3

Relative injuries of PV tissues as determined by TTC staining: (a) control and (b) after IRE treatment

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Fig. 4

Relative electrical field distributions as a function of radial distances from the center electrode versus the effects on the IRE treated PV samples

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