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Intermittent Vagus Nerve Stimulation Reflexively Modulates Heart Rate Variability in Rats With Chronic Ischemic Heart Failure

[+] Author and Article Information
Elena G. Tolkacheva

Department of Biomedical Engineering,
University of Minnesota

Manuscript received March 15, 2013; final manuscript received April 29, 2013; published online July 3, 2013. Assoc. Editor: Arthur G. Erdman.

J. Med. Devices 7(3), 030905 (Jul 03, 2013) (2 pages) Paper No: MED-13-1036; doi: 10.1115/1.4024529 History: Received March 15, 2013; Revised April 29, 2013

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Topics: Failure
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References

Sabbah, H. N.Ilsar, I., Zaretsky, A., Rastogi, S., Wang, M., and Gupta, R. C., 2011, “Vagus Nerve Stimulation in Experimental Heart Failure,” Heart Fail. Rev., 16, pp. 171–178. [CrossRef] [PubMed]
Li, M., Zheng, C., Sato, T., Kawada, T., Sugimachi, N., and Sunagawa, K., 2004, “Vagal Nerve Stimulation Markedly Improves Long-Term Survival After Chronic Heart Failure in Rats,” Circulation, 109, pp. 120–124 [CrossRef] [PubMed]
Vanoli, E., De Ferrari, G. M., Stramba-Badiale, M., Hull, S. S.Jr., Foreman, R. D., and Schwartz, P. J., 1991, “VNS and Prevention of Sudden Death in Conscious Dogs With a Healed Myocardial Infarction,” Circ Res, 68, pp. 1471–1481. [CrossRef] [PubMed]
Kunze, D. L., 1972, “Reflex Discharge Patterns of Cardiac Vagal Efferent Fibres,” J Physiol, 222, pp. 1–15. [PubMed]
Ferrari, G. M., et al. ., 2011, “Chronic Vagus Nerve Stimulation: A New and Promising Therapeutic Approach for Chronic Heart Failure,” Eur Heart J, 32(7), pp. 847–855. [CrossRef] [PubMed]
Shen, M. J., et al. ., 2011, “Continuous Low-Level Vagus Nerve Stimulation Reduces Stellate Ganglion Nerve Activity and Paroxysmal Atrial Tachyarrhythmias in Ambulatory Canines,” Circulation, 123, pp. 2204–2212. [CrossRef] [PubMed]
Litwin, S. E., Katz, S. E., Morgan, J. P., and Douglas, P. S., 1994, “Serial Echocardiographic Assessment of LV Geo and Function After Large MI in the Rat,” Circulation, 89, pp. 345–354. [CrossRef] [PubMed]
Hauptman, PJ., Schwartz, PJ., Gold, MR., et al. ., 2012, “Rationale and Study Design of the Increase of Vagal Tone in Heart Failure Study,” Am Heart J., 163(6), pp. 954–962. [CrossRef] [PubMed]

Figures

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Fig. 1

A) Raw ECG data from an Active rat. Current of 1.0 mA. B) The 1st derivative of the raw ECG data, used to remove baseline drift. C) Heart rate as a function of time. PRE, ON, and POST 7-second intervals, used for statistical analysis of HRV.

Grahic Jump Location
Fig. 2

Acute effect of VNS stimulation. HRV for PRE, ON and POST time intervals for A) sub-threshold stimulation (0.50 mA), and B) super-threshold stimulation (1.0 mA). C) HR for PRE, ON and POST time intervals for 0.50 mA and 1.0 mA VNS stimulation. ** indicates statistically significant data.

Grahic Jump Location
Fig. 3

Chronic effect of VNS stimulation on A) Average weekly HR and B) HRV for all Active and Control rats. * indicates statistically significant data.

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