Technical Briefs

Intermittent Vagus Nerve Stimulation Reflexively Modulates Heart Rate Variability in Rats With Chronic Ischemic Heart Failure

[+] Author and Article Information
Elena G. Tolkacheva

Department of Biomedical Engineering,
University of Minnesota

Manuscript received March 15, 2013; final manuscript received April 29, 2013; published online July 3, 2013. Assoc. Editor: Arthur G. Erdman.

J. Med. Devices 7(3), 030905 (Jul 03, 2013) (2 pages) Paper No: MED-13-1036; doi: 10.1115/1.4024529 History: Received March 15, 2013; Revised April 29, 2013

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Topics: Failure
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Grahic Jump Location
Fig. 3

Chronic effect of VNS stimulation on A) Average weekly HR and B) HRV for all Active and Control rats. * indicates statistically significant data.

Grahic Jump Location
Fig. 2

Acute effect of VNS stimulation. HRV for PRE, ON and POST time intervals for A) sub-threshold stimulation (0.50 mA), and B) super-threshold stimulation (1.0 mA). C) HR for PRE, ON and POST time intervals for 0.50 mA and 1.0 mA VNS stimulation. ** indicates statistically significant data.

Grahic Jump Location
Fig. 1

A) Raw ECG data from an Active rat. Current of 1.0 mA. B) The 1st derivative of the raw ECG data, used to remove baseline drift. C) Heart rate as a function of time. PRE, ON, and POST 7-second intervals, used for statistical analysis of HRV.




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