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Technical Briefs

Geometrical Optimization of V-Shaped Microcantilever for Biosensors

[+] Author and Article Information
Linxia Gu

Dept. Mechanical and Materials Engineering,
Univ. of Nebraska - Lincoln

Manuscript received March 15, 2013; final manuscript received April 26, 2013; published online July 3, 2013. Assoc. Editor: Arthur G. Erdman.

J. Med. Devices 7(3), 030936 (Jul 03, 2013) (2 pages) Paper No: MED-13-1103; doi: 10.1115/1.4024498 History: Received March 15, 2013; Revised April 26, 2013

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References

Wu, G., Datar, R. H., Hansen, K. M., Thundat, T., Cote, R. J., and Majumdar, A., 2001, “Bioassay of Prostate-Specific Antigen(PSA) Using Microcantilevers,” Nature Biotechnology, 19(9), pp. 856–860. [CrossRef] [PubMed]
Müller, K., Sainov, S., Mittler-Neher, S., Raiteri, R., Nelles, G., Butt, H. J., Knoll, W., and Skladal, P., 1999, “Sensing of Biological Substances Based on the Bending of Microfabricated Cantilevers,” Sensors and Actuators B., 61, pp. 213–217. [CrossRef]
Ji, H. F., Thundat, T., Dabestani, R., Brown, G. M., Britt, P. F., and Bonnesen, P. V., 2001, “Ultrasensitive Detection of CrO42-Using a Microcantilever Sensor,” Analytical Chemistry, 73(7), pp. 1572–1576. [CrossRef] [PubMed]
Barnes, J., Stephenson, R., Welland, M., Gerber, C., and Gimzewski, J., 1994, “Photothermal Spectroscopy With Femtojoule Sensitivity Using a Micromechanical Device,” Nature, 372(6501), pp. 79–81. [CrossRef]
Yang, K., Li, Z., Jing, Y., Chen, D., and Ye, T., editors. Research on the Resonant Frequency Formula of V-Shaped Cantilevers, 2009, IEEE.
Lakshmanan, R. S., and Mutharasan, R., 2011, “Nature of Sensitive High-Order Resonant Modes in Piezoelectric Excited Millimeter Sized Cantilever (PEMC) Sensors, Sensor Actuat a-Phys., 171(2), pp. 79–86. [CrossRef]
Goericke, F. T., and King, W. P., 2008, “Modeling Piezoresistive Microcantilever Sensor Response to Surface Stress for Biochemical Sensors,” Ieee Sens J., 8(7–8), pp. 1404–1410. [CrossRef]
Ansari, M. Z., and Cho, C., 2009, “Deflection, Frequency, and Stress Characteristics of Rectangular, Triangular, and Step Profile Microcantilevers for Biosensors,” Sensors,9(8), pp. 6046–6057.
Reed, C., Applications of Optistruct Optimization to Body in White Design. Proceedings of Altair Engineering Event, Coventry, UK, 2002.
Annicchiarico, W., and Cerrolaza, M., 2001, “Structural Shape Optimization 3D Finite-Element Models Based on Genetic Algorithms and Geometric Modeling,” Finite Elements in Analysis and Design, 37(5), pp. 403–415.

Figures

Grahic Jump Location
Fig. 1

(a) Profile of the V-shaped cantilever, and (b) the symmetry model

Grahic Jump Location
Fig. 2

Optimization flowchart

Grahic Jump Location
Fig. 3

(a) Convergence history of objective function, and (b) optimized geometry configuration

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