Design Innovation Papers

Minimizing Invasiveness of Liver Resection Using an Integrated Tissue Ablation and Division Device With Blood Flow Sensing

[+] Author and Article Information
Wei-Hsuan Huang

e-mail: g0800395@nus.edu.sg

Chee-Kong Chui

e-mail: mpecck@nus.edu.sg
Department of Mechanical Engineering,
National University of Singapore,
Singapore, 117576

Stephen K. Y. Chang

e-mail: cfscky@nus.edu.sg
Department of Surgery,
National University of Singapore,
Singapore, 119228

1Corresponding author.

Manuscript received January 31, 2012; final manuscript received May 23, 2013; published online September 24, 2013. Assoc. Editor: Just L. Herder.

J. Med. Devices 7(4), 045001 (Sep 24, 2013) (5 pages) Paper No: MED-12-1010; doi: 10.1115/1.4025181 History: Received January 31, 2012; Revised May 23, 2013

Liver cancer is the fifth most common cancer. Liver resection or hepatectomy has been performed to remove the cancerous portion of the liver organ. This paper reports an integrated surgical mechatronic device that minimizes blood loss during tissue resection and prevents excessive tissue ablation. The novel device integrates radio-frequency electrodes to induce coagulation to the blood vessels, a laser Doppler sensor to detect the stoppage of blood flow, and a retractable knife blade to divide the ablated tissue. Finite element simulation was used to improve upon the placement design of electrodes. Effectiveness of this device in reducing the invasiveness of tissue division was demonstrated with in vitro and in vivo animal experiments.

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Fig. 1

(a) Tissue ablation and division prototype device. (b) Modular design of the prototype device.

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Fig. 2

Position of various parts

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Fig. 3

(a) Temperature distribution for four-electrodes RF ablation. (b) Temperature distribution for two-electrodes RF ablation.

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Fig. 4

User interface for LDF information display

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Fig. 5

(a) Calibration of LDF sensor with water. (b) Calibration of LDF sensor with milk.

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Fig. 6

Knife blade visibility. (L to R) Small square blade, large surgical blade, large square blade.

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Fig. 7

Device in use during in-vivo testing



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