Frontiers Abstracts

Modeling the Role of Oscillator Flow and Dynamic Mechanical Conditioning on Dense Connective Tissue Formation in Mesenchymal Stem Cell–Derived Heart Valve Tissue Engineering

[+] Author and Article Information
João S. Soares

Institute for Computational Engineering and Sciences,
University of Texas at Austin,
Austin, TX 78712

Fotis Sotiropoulos

Saint Anthony Falls Laboratory,
Department of Civil Engineering,
University of Minnesota,
Minneapolis, MN 55414

Michael S. Sacks

Institute for Computational Engineering and Sciences,
Department of Biomedical Engineering,
University of Texas at Austin,
Austin, TX 78712

Manuscript received October 1, 2013; final manuscript received November 5, 2013; published online December 5, 2013. Assoc. Editor: Wei Sun.

J. Med. Devices 7(4), 040927 (Dec 05, 2013) (2 pages) Paper No: MED-13-1248; doi: 10.1115/1.4025984 History: Received October 01, 2013; Revised November 05, 2013

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Grahic Jump Location
Fig. 1

Velocity flow field and distribution of oscillatory shear index on construct surfaces (Re = 1376)

Grahic Jump Location
Fig. 2

Spatial distribution of ECM (nondimensional) in a cross-section of the nondeformed and flexed TEHV leaflet constructs. Highly oscillatory flows enhance oxygen transport, cell growth, and matrix production in the bottom surface of the flexed scaffold.




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