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Frontiers Abstracts

Modeling the Role of Oscillator Flow and Dynamic Mechanical Conditioning on Dense Connective Tissue Formation in Mesenchymal Stem Cell–Derived Heart Valve Tissue Engineering

[+] Author and Article Information
João S. Soares

Institute for Computational Engineering and Sciences,
University of Texas at Austin,
Austin, TX 78712

Fotis Sotiropoulos

Saint Anthony Falls Laboratory,
Department of Civil Engineering,
University of Minnesota,
Minneapolis, MN 55414

Michael S. Sacks

Institute for Computational Engineering and Sciences,
Department of Biomedical Engineering,
University of Texas at Austin,
Austin, TX 78712

Manuscript received October 1, 2013; final manuscript received November 5, 2013; published online December 5, 2013. Assoc. Editor: Wei Sun.

J. Med. Devices 7(4), 040927 (Dec 05, 2013) (2 pages) Paper No: MED-13-1248; doi: 10.1115/1.4025984 History: Received October 01, 2013; Revised November 05, 2013

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References

Stock, U. A., Vacanti, J. P., Mayer, Jr., J. E., and Wahlers, T., 2002, “Tissue Engineering of Heart Valves—Current Aspects,” Thorac. Cardiovasc. Surg., 50, pp. 184–193. [CrossRef] [PubMed]
Ramaswamy, S., Gottlieb, D., Engelmayr, Jr., G. C., Aikawa, E., Schmidt, D. E., Gaitan-Leon, D. M., Sales, V. L., Mayer, Jr., J. E., and Sacks, M. S., 2010, “The Role of Organ Level Conditioning on the Promotion of Engineered Heart Valve Tissue Development In Vitro Using Mesenchymal Stem Cells,” Biomaterials, 31, pp. 1114–1125. [CrossRef] [PubMed]
Engelmayr, Jr., G. C., Rabkin, E., Sutherland, F. W., Schoen, F. J., Mayer, Jr., J. E., and Sacks, M. S., 2005, “The Independent Role of Cyclic Flexure in the Early In Vitro Development of an Engineered Heart Valve Tissue,” Biomaterials, 26, pp. 175–187. [CrossRef] [PubMed]
Engelmayr, Jr., G. C., Sales, V. L., Mayer, Jr., J. E., and Sacks, M. S., 2006, “Cyclic Flexure and Laminar Flow Synergistically Accelerate Mesenchymal Stem Cell-Mediated Engineered Tissue Formation: Implications for Engineered Heart Valve Tissues,” Biomaterials, 27, pp. 6083–6095. [CrossRef] [PubMed]
Engelmayr, Jr., G. C., Soletti, L., Vigmostad, S. C., Budilarto, S. G., Federspiel, W. J., Chandran, K. B., Vorp, D. A., and Sacks, M. S., 2008, “A Novel Flex-Stretch-Flow Bioreactor for the Study of Engineered Heart Valve Tissue Mechanobiology,” Ann. Biomed. Eng., 36, pp. 700–712. [CrossRef] [PubMed]

Figures

Grahic Jump Location
Fig. 1

Velocity flow field and distribution of oscillatory shear index on construct surfaces (Re = 1376)

Grahic Jump Location
Fig. 2

Spatial distribution of ECM (nondimensional) in a cross-section of the nondeformed and flexed TEHV leaflet constructs. Highly oscillatory flows enhance oxygen transport, cell growth, and matrix production in the bottom surface of the flexed scaffold.

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