0
Technical Brief

Development of a Simple Miniature Thermochemical Ablation Device Suitable for Tumor Ablation Research in Rodent Models

[+] Author and Article Information
Erik N. K. Cressman

e-mail: cress013@umn.edu

Anthony P. Zbacnik

Department of Radiology,
University of Minnesota,
424 Delaware Street, SE MMC 292,
Minneapolis, MN 55455

1Corresponding author.

Manuscript received November 13, 2012; final manuscript received July 19, 2013; published online December 6, 2013. Assoc. Editor: Carl A. Nelson.

J. Med. Devices 8(1), 014501 (Dec 06, 2013) (3 pages) Paper No: MED-12-1144; doi: 10.1115/1.4025187 History: Received November 13, 2012; Revised July 19, 2013

Thermochemical ablation is a recently developed minimally invasive method with potential for solid tumor treatment such as in liver cancer. A recently described prototype device, however, is too large for use in the more common rodent models of cancer. In this report we describe a simple, low-cost variant of the device that is easy to assemble, small enough to be readily applicable to small animal models, and then demonstrate its use in an ex vivo model for ablation. It should therefore enable study of the method without requiring specialized equipment or access to a machine shop for device manufacture.

FIGURES IN THIS ARTICLE
<>
Copyright © 2014 by ASME
Your Session has timed out. Please sign back in to continue.

References

Siegel, R., Ward, E., Brawley, O., and Jemal, A., 2011, “Cancer Statistics, 2011: The Impact of Eliminating Socioeconomic and Racial Disparities on Premature Cancer Deaths,” Ca-Cancer J. Clin., 61(4), pp. 212–236. [CrossRef] [PubMed]
Ferenci, P., Fried, M., Labrecque, D., Bruix, J., Sherman, M., Omata, M., Heathcote, J., Piratsivuth, T., Kew, M., Otegbayo, J. A., Zheng, S. S., Sarin, S., Hamid, S. S., Modawi, S. B., Fleig, W., Fedail, S., Thomson, A., Khan, A., Malfertheiner, P., Lau, G., Carillo, F. J., Krabshuis, J., and Le Mair, A., 2010, “Hepatocellular Carcinoma (HCC): A Global Perspective,” J. Gastrointest Liver Dis., 44(4), pp. 239–245. [CrossRef]
Kim, D. Y., and Han, K., 2012, “Epidemiology and Surveillance of Hepatocellular Carcinoma,” Liver Cancer, 1(1), pp. 2–14. [CrossRef] [PubMed]
El-Serag, H. B., and Rudolph, K. L., 2007, “Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis,” Gastroenterology, 132(7), pp. 2557–2576. [CrossRef] [PubMed]
Bruix, J., and Lindor, K., 2009, “The Need for Novel and Interesting Data in Liver Cancer Research,” Hepatology, 50(6), pp. 1690–1691. [CrossRef] [PubMed]
Bruix, J., and Llovet, J. M., 2009, “Major Achievements in Hepatocellular Carcinoma,” Lancet, 373(9664), pp. 614–616. [CrossRef] [PubMed]
Lau, W. Y., Leung, T. W., Yu, S. C., and Ho, S. K. W., 2003, “Percutaneous Local Ablative Therapy for Hepatocellular Carcinoma: A Review and Look into the Future,” Ann. Surg., 237(2), pp. 171–179. [CrossRef] [PubMed]
Lencioni, R., 2010, “Loco-Regional Treatment of Hepatocellular Carcinoma in the Era of Molecular Targeted Therapies,” Oncology, 78(Suppl 1), pp. 107–112. [CrossRef] [PubMed]
Misselt, A. J., Edelman, T. L., Choi, J. H., Bischof, J. C., and Cressman, E. N. K., 2009, “A Hydrophobic Gel Phantom for Study of Thermochemical Ablation: Initial Results using a Weak Acid and Weak Base,” J. Vasc. Intervent. Radiol., 20(10), pp. 1352–1358. [CrossRef]
Farnam, J. L., Smith, B. C., Johnson, B. R., Estrada, R., Edelman, T. L., Farah, R., and Cressman, E. N. K., 2010, “Thermochemical Ablation in an Ex-Vivo Porcine Liver Model Using Acetic Acid and Sodium Hydroxide: Proof of Concept,” J. Vasc. Intervent. Radiol., 21(10), pp. 1573–1578. [CrossRef]
Freeman, L. A., Anwer, B., Brady, R. P., Smith, B. C., Edelman, T. L., Misselt, A. J., and Cressman, E. N. K., 2010, “In Vitro Thermal Profile Suitability Assessment of Acids and Bases for Thermochemical Ablation: Underlying Principles,” J. Vasc. Intervent. Radiol., 21(3), pp. 381–385. [CrossRef]
Cressman, E. N., Tseng, H. J., Talaie, R., and Henderson, B. M., 2010, “A New Heat Source for Thermochemical Ablation Based on Redox Chemistry: Initial Studies Using Permanganate,” Int. J. Hypertherm., 26(4), pp. 327–337. [CrossRef]
Deng, Z. S., and Liu, J., 2007, “Minimally Invasive Thermotherapy Method for Tumor Treatment Based on an Exothermic Chemical Reaction,” Minimally Invasive Ther. Allied Technol., 16(6), pp. 341–346. [CrossRef]
Cressman, E. N. K., 2012, Physics of Thermal Therapy Fundamentals and Clinical Applications, CRC Press, Boca Raton, FL, pp. 339–351.
Rao, W., and Liu, J., 2009, “Injectable Liquid Alkali Alloy Based-Tumor Thermal Ablation Therapy,” Minimally Invasive Ther. Allied Technol., 18(1), pp. 30–35. [CrossRef]
Cressman, E. N., and Jahangir, D. A., 2013, “Dual Mode Single Agent Thermochemical Ablation by Simultaneous Release of Heat Energy and Acid: Hydrolysis of Electrophiles,” Int. J. Hypertherm., 29(1), pp. 71–78. [CrossRef]
Geeslin, M. G., and Cressman, E. N. K., 2012, “Thermochemical Ablation: A Device for a Novel Interventional Concept,” J. Med. Dev., 6(1) p. 015001. [CrossRef]
Cressman, E. N. K., Shenoi, M. M., Edelman, T. L., Geeslin, M. G., Hennings, L. J., Zhang, Y., Iaizzo, P. A., and Bischof, J. C., 2012, “In Vivo Comparison of Simultaneous Versus Sequential Injection Technique for Thermochemical Ablation in a Porcine Model,” Int. J. Hyperthermia, 28(2), pp. 105–112. [CrossRef] [PubMed]
Cressman, E. N. K., Geeslin, M. G., Shenoi, M. M., Hennings, L. J., Zhang, Y., Iaizzo, P. A., and Bischof, J. C., 2012, “Concentration and Volume Effects in Thermochemical Ablation in Vivo: Results in a Porcine Model,” Int J Hyperthermia, 28(2), pp. 113–121. [CrossRef] [PubMed]
Baldwin, R., 1996, “How Hofmeister Ion Interactions Affect Protein Stability,” Biophys. J., 71(4), pp. 2056–2063. [CrossRef] [PubMed]
Shimizu, S., McLaren, W. M., and Matubayasi, N., 2006, “The Hofmeister Series and Protein-Salt Interactions,” J. Chem. Phys., 124, p. 234905. [CrossRef] [PubMed]

Figures

Grahic Jump Location
Fig. 1

Device (no delivery needle attached) with blunt needle tips extending just beyond terminus of Luer lock fitting. Inner portion of cap has been filled with cyanoacrylate glue to eliminate dead space and tips extend slightly to occupy space within the receiving (delivery) needle hub.

Grahic Jump Location
Fig. 2

Device assembled with delivery needle, two delivery syringes, and extension tubing attached. Each syringe would be loaded and device primed prior to connection to final delivery needle. Final needle can be connected immediately, or inserted into target tissue prior to connection depending on circumstances. A syringe pump may also be used for precise control over injection rates.

Grahic Jump Location
Fig. 3

Temperature data obtained using a thermocouple thermometer from injections of 0.25 mL each of 11M HCl and NaOH. Arrowhead in each case indicates time point for injection, which was performed after a brief period to establish the baseline temperature. Temperature increases of approximately 25 °C were noted within seconds after initiating each injection.

Grahic Jump Location
Fig. 4

Gross photos of lesions created injecting 0.25 mL, 11M HCl simultaneously with 0.25 mL, 11M NaOH. Pale, tan coagulation zones are clearly visible measuring from 1–1.5 cm in diameter. Product of the reaction in tissues is NaCl.

Tables

Errata

Discussions

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In