Technical Brief

Development of a Simple Miniature Thermochemical Ablation Device Suitable for Tumor Ablation Research in Rodent Models

[+] Author and Article Information
Erik N. K. Cressman

e-mail: cress013@umn.edu

Anthony P. Zbacnik

Department of Radiology,
University of Minnesota,
424 Delaware Street, SE MMC 292,
Minneapolis, MN 55455

1Corresponding author.

Manuscript received November 13, 2012; final manuscript received July 19, 2013; published online December 6, 2013. Assoc. Editor: Carl A. Nelson.

J. Med. Devices 8(1), 014501 (Dec 06, 2013) (3 pages) Paper No: MED-12-1144; doi: 10.1115/1.4025187 History: Received November 13, 2012; Revised July 19, 2013

Thermochemical ablation is a recently developed minimally invasive method with potential for solid tumor treatment such as in liver cancer. A recently described prototype device, however, is too large for use in the more common rodent models of cancer. In this report we describe a simple, low-cost variant of the device that is easy to assemble, small enough to be readily applicable to small animal models, and then demonstrate its use in an ex vivo model for ablation. It should therefore enable study of the method without requiring specialized equipment or access to a machine shop for device manufacture.

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Grahic Jump Location
Fig. 2

Device assembled with delivery needle, two delivery syringes, and extension tubing attached. Each syringe would be loaded and device primed prior to connection to final delivery needle. Final needle can be connected immediately, or inserted into target tissue prior to connection depending on circumstances. A syringe pump may also be used for precise control over injection rates.

Grahic Jump Location
Fig. 1

Device (no delivery needle attached) with blunt needle tips extending just beyond terminus of Luer lock fitting. Inner portion of cap has been filled with cyanoacrylate glue to eliminate dead space and tips extend slightly to occupy space within the receiving (delivery) needle hub.

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Fig. 3

Temperature data obtained using a thermocouple thermometer from injections of 0.25 mL each of 11M HCl and NaOH. Arrowhead in each case indicates time point for injection, which was performed after a brief period to establish the baseline temperature. Temperature increases of approximately 25 °C were noted within seconds after initiating each injection.

Grahic Jump Location
Fig. 4

Gross photos of lesions created injecting 0.25 mL, 11M HCl simultaneously with 0.25 mL, 11M NaOH. Pale, tan coagulation zones are clearly visible measuring from 1–1.5 cm in diameter. Product of the reaction in tissues is NaCl.




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