Frontiers Abstracts

Multiscale Modeling of Flow Induced Thrombogenicity With Dissipative Particle Dynamics and Molecular Dynamics

[+] Author and Article Information
Danny Bluestein, João S. Soares, Peng Zhang, Chao Gao

Department of Biomedical Engineering,
Stony Brook University,
Stony Brook, NY 11794

Seetha Pothapragada, Na Zhang, Yuefan Deng

Department of Applied Mathematics and Statistics,
Stony Brook University,
Stony Brook, NY 11794

Marvin J. Slepian

Sarver Heart Center,
University of Arizona,
Tucson, AZ 85721

Manuscript received September 15, 2013; final manuscript received October 17, 2013; published online April 28, 2014. Editor: Gerald E. Miller.

J. Med. Devices 7(4), 024502 (Apr 28, 2014) (2 pages) Paper No: MED-13-1211; doi: 10.1115/1.4027347 History: Received September 15, 2013; Revised October 17, 2013

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Xenos, M., Girdhar, G., Alemu, Y., Jesty, J., Slepian, M., Einav, S., and Bluestein, D., 2010, “Device Thrombogenicity Emulator (DTE)—Design Optimization Methodology for Cardiovascular Devices: A Study in Two Bileaflet MHV Designs,” J. Biomech., 43(12), 2400–2409. [CrossRef] [PubMed]


Grahic Jump Location
Fig. 1

(a)–(c) 3D cell model geometry of the simulated platelet. Platelet boundary coordinates from SEM images at (d) 1 dyn/cm2—4 min, (e) 70 dyn/cm2—4 min, and (f) 70 dyn/cm2—0 min, with ((g)–(i)) corresponding simulation results.



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