Technical Brief

Validation of Peripheral Pulse Wave Analysis Technique to Detect Aortic Valve State in Continuous-Flow LVADs1

[+] Author and Article Information
Ashish Singal

Department of Biomedical Engineering;
Department of Surgery;
Department of Medical Devices Center;
Department of Cardiovascular Division,
University of Minnesota,
B172 Mayo, MMC 195,
420 Delaware Street S.E.,
Minneapolis, MN 55455

Aimee Hamel, Matt Larson, Peter Eckman

Cardiovascular Division,
University of Minnesota,
Mayo Mail Code 508,
420 Delaware St. S.E.,
Minneapolis, MN 55455

Harrison Kelner

Cardiovascular Division,
University of Minnesota,
Mayo Mail Code 508,
420 Delaware St. S.E.,
Minneapolis, MN 55455

Evan Johnson

Biomedical Engineering,
7-105 Hasselmo Hall,
University of Minnesota,
312 Church St. S.E.,
Minneapolis, MN 55455

Accepted and presented at the Design of Medical Devices Conference (DMD2014), Minneapolis, MN, April 7–10, 2014.

Manuscript received February 21, 2014; final manuscript received February 28, 2014; published online April 28, 2014. Editor: Arthur G. Erdman.

J. Med. Devices 8(2), 020903 (Apr 28, 2014) (3 pages) Paper No: MED-14-1032; doi: 10.1115/1.4027003 History: Received February 21, 2014; Revised February 28, 2014

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Thayer, J. F., Yamamoto, S. S., and Brosschot, J. F., 2010, “The Relationship of Autonomic Imbalance, Heart Rate Variability and Cardiovascular Disease Risk Factors,” Int. J. Cardiol., 141(2), pp. 122–131. [CrossRef]
Singal, A., Oura, M., Almekkawy, M., Hamel, A., Larson, M., and Eckman, P., 2013, “Device Optimization Using Pulse Wave Analysis Techniques,” ASME J. Med. Devices, 7(2), p. 020903. [CrossRef]


Grahic Jump Location
Fig. 5

A representative example illustrating signature detection of aortic valve opening and closing via individual frequency components and ratio of frequency components

Grahic Jump Location
Fig. 4

PAT signal and corresponding PS at increasing pump speeds acquired during echo ramp-speed study

Grahic Jump Location
Fig. 3

Correlation between PAT signal amplitude and PI

Grahic Jump Location
Fig. 2

Similar frequency distribution of frequency components in central pressures and peripheral signals

Grahic Jump Location
Fig. 1

Signatures of fundamental, first, and second harmonic frequency components illustrating correlation between central pressures and peripheral signals



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