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Technical Brief

Physiological Tissue Response to Various Ablative Modalities1

[+] Author and Article Information
Ashish Singal

Department of Surgery;
Department Biomedical Engineering,
University of Minnesota,
Minneapolis, MN 55455

Charles L. Soule

Department of Surgery,
University of Minnesota
Minneapolis, MN 55455

John R. Ballard

Department of Electrical and
Computer Engineering;
Department of Medical Devices Center,
University of Minnesota,
Minneapolis, MN 55455

Erik N. Cressman

Department of Interventional Radiology,
University of Minnesota,
Minneapolis, MN 55455

Paul A. Iaizzo

Department of Surgery;
Department Biomedical Engineering;
Department of Integrative Biology & Physiology;
Institute for Engineering in Medicine,
University of Minnesota,
Minneapolis, MN 55455

Accepted and presented at the Design of Medical Devices Conference (DMD2014), Minneapolis, MN, April 7–10, 2014.

Manuscript received February 21, 2014; final manuscript received February 28, 2014; published online April 28, 2014. Editor: Arthur G. Erdman.

J. Med. Devices 8(2), 020906 (Apr 28, 2014) (3 pages) Paper No: MED-14-1035; doi: 10.1115/1.4027006 History: Received February 21, 2014; Revised February 28, 2014

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Figures

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Fig. 1

System used to acquire peak-force and baseline-force data simultaneously from 16 tissue baths (four shown)

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Fig. 2

Dose effects of RF ablations on percent reductions in stimulated peak-forces of swine diaphragm bundles (n = 5)

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Fig. 3

Dose effects of cryoablation on percent reductions in stimulated peak-forces of swine diaphragm bundles (n = 3)

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Fig. 4

Dose effects of chemo-ablation with 8 M urea on percent reductions in stimulated peak-force of swine diaphragm bundles (n = 4)

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Fig. 5

Dose effects of RF ablations on percent changes in baseline-forces of swine diaphragm bundles (n = 5)

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Fig. 6

Dose effects of cryoablation on percent changes in baseline-forces of swine diaphragm bundles (n = 3)

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Fig. 7

Dose effects of chemo-ablation with 8 M urea on percent changes in baseline-forces of swine diaphragm bundles (n = 4)

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