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Technical Brief

Miniaturized Radio Frequency Telemetric Pacemaker With Anti-Arrhythmic Pacing Protocol1

[+] Author and Article Information
Kanchan Kulkarni, Sze Yuen Tan, Elena G. Tolkacheva

Department of Biomedical Engineering,
University of Minnesota,
312 Church St. S.E.,
Minneapolis, MN 55455

Accepted and presented at the Design of Medical Devices Conference (DMD2014), Minneapolis, MN, April 7–10, 2014.

Manuscript received February 21, 2014; final manuscript received February 28, 2014; published online April 28, 2014. Editor: Arthur G. Erdman.

J. Med. Devices 8(2), 020909 (Apr 28, 2014) (2 pages) Paper No: MED-14-1038; doi: 10.1115/1.4027009 History: Received February 21, 2014; Revised February 28, 2014

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References

Karma, A., 1994, “Electrical Alternans and Spiral Wave Breakup in Cardiac Tissue,” Chaos, 4(3), pp. 461–472. [CrossRef]
Watanabe, M. A., Otani, N. F., and Gilmour, Jr., R. F.1995, “Biphasic Restitution of Action Potential Duration and Complex Dynamics in Ventricular Myocardium,” Circ. Res., 76(5), pp. 915–921. [CrossRef]
Koller, M. L., Riccio, M. L., and Gilmour, Jr., R. F., 1998, “Dynamic Restitution of Action Potential Duration During Electrical Alternans and Ventricular Fibrillation,” Am. J. Physiol., 275(5), pp. H1635–H1642.
Malik, M., and Camm, A. J., 1995, Heart Rate Variability, Futura Publishing Co., Armonk, NY.
Goldberger, A. L., Amaral, L. A. N., Glass, L., Hausdorff, J. M., Ivanov, P. C., Mark, R. G., Mietus, J. E., Moody, G. B., Peng, C.-K., and Stanley, H. E., 2000, “PhysioBank, PhysioToolkit, and PhysioNet: Components of a New Research Resource for Complex Physiologic Signals,” Circulation, 101(23), pp. e215–e220. [CrossRef]
Dvir, H., and Zlochiver, S., 2013, “Stochastic Cardiac Pacing Increases Ventricular Electrical Stability—A Computational Study,” Biophys. J., 105(2), pp. 533–542. [CrossRef]
Kleiger, R. E., Miller, J. P., Bigger, J. T., and Moss, A. J., 1987, “Decreased Heart Rate Variability and Its Association With Increased Mortality After Acute Myocardial Infarction,” Am. J. Cardiol., 59(4), pp. 256–262. [CrossRef]
La Rovere, M. T., Pinna, G. D., Maestri, R., Mortara, A., Capomolla, S., Febo, O., Ferrari, R., Franchini, M., Gnemmi, M., Opasich, C., Riccardi, P. G., Traversi, E., and Cobelli, F., 2003, “Short-Term Heart Rate Variability Strongly Predicts Sudden Cardiac Death in Chronic Heart Failure Patients,” Circulation, 107(4), pp. 565–570. [CrossRef]
McIntyre, S., Kakade, V., Mori, Y., and Tolkacheva, E. G., 2014, “Heart Rate Variability and Alternans Formation in the Heart: The Role of Feedback in Cardiac Dynamics,” J. Theor. Biol. (in press). [CrossRef]
Viskin, S., Glikson, M., Fish, R., Glick, A., Copperman, Y., and Saxon, L. A., 2000, “Rate Smoothing With Cardiac Pacing for Preventing Torsade de Pointes,” Am. J. Cardiol., 86(9), pp. 111K–115K. [CrossRef]

Figures

Grahic Jump Location
Fig. 1

HRV presented as change in RR interval for a normal sinus rhythm (adapted from Ref. [5])

Grahic Jump Location
Fig. 2

Circuit implanted in the animal

Grahic Jump Location
Fig. 3

External processing unit

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