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Technical Brief

Design and Characterization of an Endovascular Mechanical Thrombectomy Device1

[+] Author and Article Information
Jason M. Szafron

Department of Biomedical Engineering,
Texas A&M University,
5045 Emerging Technologies Building,
3120 TAMU,
College Station, TX 77843

Andrea D. Muschenborn, Duncan J. Maitland

Department of Biomedical Engineering,
Texas A&M University,
5045 Emerging Technologies Building,
3120 TAMU,
College Station, TX 77843

Accepted and presented at the Design of Medical Devices Conference (DMD2014), Minneapolis, MN, April 7–10, 2014.

Manuscript received February 21, 2014; final manuscript received February 28, 2014; published online April 28, 2014. Editor: Arthur G. Erdman.

J. Med. Devices 8(2), 020910 (Apr 28, 2014) (2 pages) Paper No: MED-14-1039; doi: 10.1115/1.4027010 History: Received February 21, 2014; Revised February 28, 2014

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References

Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., and Fox, C. S., 2012, “Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association,” Circulation, 125(1), pp. e2–e220. [CrossRef]
Small, W., Wilson, T. S., Buckley, P. R., Benett, W. J., Loge, J. M., Hartman, J., and Maitland, D. J., 2007, “Prototype Fabrication and Preliminary In Vitro Testing of a Shape Memory Endovascular Thrombectomy Device,” IEEE Trans. Biomed. Eng., 54(9), pp. 1657–1666. [CrossRef]
Castaño, C., Dorado, L., Guerrero, C., Millán, M., Gomis, M., de la Ossa, N. P., Castellanos, M., García, M. R., Domenech, S., and Dávalos, A., 2010, “Mechanical Thrombectomy With the Solitaire AB Device in Large Artery Occlusions of the Anterior Circulation: A Pilot Study,” Stroke, 41(8), pp. 1836–1840. [CrossRef]
Singhal, P., Rodriguez, J. N., Small, W., Eagleston, S., Van de Water, J., Maitland, D. J., and Wilson, T. S., 2012, “Ultra Low Density and Highly Crosslinked Biocompatible Shape Memory Polyurethane Foams,” J. Polym. Sci. Part B: Polym. Phys., 50(10), pp. 724–737. [CrossRef]
Gralla, J., Schroth, G., Remonda, L., Fleischmann, A., Fandino, J., Slotboom, J., and Brekenfeld, C., 2006, “A Dedicated Animal Model for Mechanical Thrombectomy in Acute Stroke,” Am. J. Neuroradiol., 27(6), pp. 1357–1361.
Hwang, W., Volk, B. L., Akberali, F., Singhal, P., Criscione, J. C., and Maitland, D. J., 2012, “Estimation of Aneurysm Wall Stresses Created by Treatment With a Shape Memory Polymer Foam Device,” Biomech. Model. Mechanobiol., 11(5), pp. 715–729. [CrossRef]

Figures

Grahic Jump Location
Fig. 1

Nitinol support piece iterations. Changes were made to each iteration based on observations of the failure mechanism of the previous design.

Grahic Jump Location
Fig. 3

Each pane shows the progression of the device as the blood clot is retracted through the bifurcation of the vessel model

Grahic Jump Location
Fig. 2

Ultimate failure force for each tensile test trial for each design. Labels correspond to designs in Fig. 1.

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