Technical Brief

Neuromodulation on Bladder Capacity in Conscious Sheep1

[+] Author and Article Information
Xin Su, Thaddeus Brink, Dwight E. Nelson

Global Neuromodulation Research,
Minneapolis, MN 55432

Angela Nickles

Physiology Research Laboratory,
Minneapolis, MN 55432

Accepted and presented at the Design of Medical Devices Conference (DMD2014), Minneapolis, MN, April 7–10, 2014.

Manuscript received February 21, 2014; final manuscript received February 28, 2014; published online April 28, 2014. Editor: Arthur G. Erdman.

J. Med. Devices 8(2), 020924 (Apr 28, 2014) (2 pages) Paper No: MED-14-1052; doi: 10.1115/1.4027023 History: Received February 21, 2014; Revised February 28, 2014

First Page Preview

View Large
First page PDF preview
Copyright © 2014 by ASME
Your Session has timed out. Please sign back in to continue.



Grahic Jump Location
Fig. 1

Representative recording prior to ((a), no stim) and with (b) bilateral sacral neuromodulation at VMax (VMax stim, 10 Hz, pulse-width = 0.21 ms). Time scale is shown above the graph.

Grahic Jump Location
Fig. 2

Effects of sacral neuromodulation on bladder capacity measured using urodynamics. Filled symbols denote measures during stimulation. Open symbols are measures without stimulation. Sacral neuromodulation during voids 4–5 applied at VTh (10 Hz, 0.21 ms pulse-width) caused no change in capacity while stimulation at VMax caused transient but nonsignificant increases in mean capacity. On a subsequent test, neuromodulation during voids 4–10 induced significant increases in capacity over baseline. Responses are represented as a percentage of baseline control capacities (mean of voids 2–3).




Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In