Technical Brief

A Computational Framework to Evaluate the Effectiveness of Intrasaccular Therapies for Cerebral Aneurysms1

[+] Author and Article Information
Ashok Nageswaran, Rahul Ramachandran, Ananthkrishnan Gopalakrishnan

Department of Mechanical Engineering,
University of Cincinnati,
Cincinnati, OH 45221

Todd Abruzzo

University of Cincinnati College of Medicine,
Cincinnati, OH 45229

Balakrishna Haridas

Department of Biomedical Engineering,
University of Cincinnati,
Cincinnati, OH 45221

Accepted and presented at the Design of Medical Devices Conference (DMD2014), Minneapolis, MN, April 7–10, 2014.

Manuscript received February 21, 2014; final manuscript received March 3, 2014; published online April 28, 2014. Editor: Arthur G. Erdman.

J. Med. Devices 8(2), 020943 (Apr 28, 2014) (2 pages) Paper No: MED-14-1092; doi: 10.1115/1.4027050 History: Received February 21, 2014; Revised March 03, 2014

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Ramachandran, R., 2008, “A Nonlinear Stress Sensitivity Study on Role of Coil-Thrombus Complex in Reduction of Idealized Cerebral Aneurysm Wall Stresses,” M.S. thesis, University of Cincinnati, Cincinnati, OH.
Gopalakrishnan, A., 2008, “Evaluating the Effectiveness of Coil Embolization Endovascular Therapy in Reducing Wall Stresses in Patient Specific Intracranial Aneurysms: A Nonlinear Computational Sensitivity Study,” M.S. thesis, University of Cincinnati, Cincinnati, OH.
Weidner, C., Abruzzo, T., and Haridas, B., 2007, “Mechanical Properties of Acutely Formed Thrombus and Guglielmi Detachable Coils: Implications for Protection of Completely and Partially Occluded Aneurysms,” International Stroke Conference, San Francisco, CA, February 7–9, Paper No. P496.


Grahic Jump Location
Fig. 1

Patient specific aneurysm model. Surface rendered CTA image (left), FE model (right).

Grahic Jump Location
Fig. 2

% reduction in wall stress in idealized aneurysm model

Grahic Jump Location
Fig. 3

% reduction in wall stress in patient specific aneurysm model




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