Technical Brief

Computational Framework for Modeling In-Stent Restenosis1

[+] Author and Article Information
Shijia Zhao, Linxia Gu

Department of Mechanical and Materials Engineering,
University of Nebraska-Lincoln,
Lincoln, NE 68508

Accepted and presented at the Design of Medical Devices Conference (DMD2014), Minneapolis, MN, April 7-10, 2014. DOI: 10.1115/1.4027062

Manuscript received February 21, 2014; final manuscript received March 3, 2014; published online April 28, 2014. Editor: Arthur G. Erdman.

J. Med. Devices 8(2), 020947 (Apr 28, 2014) (2 pages) Paper No: MED-14-1096; doi: 10.1115/1.4027062 History: Received February 21, 2014; Revised March 03, 2014

First Page Preview

View Large
First page PDF preview
Copyright © 2014 by ASME
Your Session has timed out. Please sign back in to continue.


Marque, V., Kieffer, P., Atkinson, J., and Lartaud-Idjouadiene, I., 1999, “Elastic Properties and Composition of the Aortic Wall in Old Spontaneously Hypertensive Rats,” Hypertension, 34(3), pp. 415–422. [CrossRef]
Komatsu, R., Ueda, M., Naruko, T., Kojima, A., and Becker, A. E., 1998, “Neointimal Tissue Response at Sites of Coronary Stenting in Humans Macroscopic, Histological, and Immunohistochemical Analyses,” Circulation, 98(3), pp. 224–233. [CrossRef]
Rachev, A., Stergiopulos, N., and Meister, J., 1998, “A Model for Geometric and Mechanical Adaptation of Arteries to Sustained Hypertension,” ASME J. Biomech. Eng., 120(1), pp. 9–17. [CrossRef]
Taber, L., 1998, “A Model for Aortic Growth Based on Fluid Shear and Fiber Stresses,” ASME J. Biomech. Eng., 120(3), pp. 348–354. [CrossRef]
Alford, P., Humphrey, J., and Taber, L., 2008, “Growth and Remodeling in a Thick-Walled Artery Model: Effects of Spatial Variations in Wall Constituents,” Biomech. Model. Mechanobiol., 7(4), pp. 245–262. [CrossRef]
Humphrey, J. D., 2001, “Stress, Strain, and Mechanotransduction in Cells,” ASME J. Biomech. Eng., 123(6), pp. 638–641. [CrossRef]
Gleason, R., and Humphrey, J. D., 2005, “A Mixture Model of Arterial Growth and Remodeling in Hypertension: Altered Muscle Tone and Tissue Turnover,” J. Vasc. Res., 41(4), pp. 352–363. [CrossRef]
Javier, R., Goicolea, J., and Felipe, G., 2007, “A Volumetric Model for Growth of Arterial Walls With Arbitrary Geometry and Loads,” J. Biomech., 40(5), pp. 961–971. [CrossRef]


Grahic Jump Location
Fig. 1.

The computational model for artery remodeling

Grahic Jump Location
Fig. 2

The remodeling process of restenosis formation induced by stent, including the first to eighth phase (from left to right and up to down)

Grahic Jump Location
Fig. 3

The comparison of von Mises stress of the artery before (left) and after (right) the remodeling process



Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In