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Technical Brief

Computational Framework for Modeling In-Stent Restenosis1

[+] Author and Article Information
Shijia Zhao, Linxia Gu

Department of Mechanical and Materials Engineering,
University of Nebraska-Lincoln,
Lincoln, NE 68508

Accepted and presented at the Design of Medical Devices Conference (DMD2014), Minneapolis, MN, April 7-10, 2014. DOI: 10.1115/1.4027062

Manuscript received February 21, 2014; final manuscript received March 3, 2014; published online April 28, 2014. Editor: Arthur G. Erdman.

J. Med. Devices 8(2), 020947 (Apr 28, 2014) (2 pages) Paper No: MED-14-1096; doi: 10.1115/1.4027062 History: Received February 21, 2014; Revised March 03, 2014

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References

Marque, V., Kieffer, P., Atkinson, J., and Lartaud-Idjouadiene, I., 1999, “Elastic Properties and Composition of the Aortic Wall in Old Spontaneously Hypertensive Rats,” Hypertension, 34(3), pp. 415–422. [CrossRef]
Komatsu, R., Ueda, M., Naruko, T., Kojima, A., and Becker, A. E., 1998, “Neointimal Tissue Response at Sites of Coronary Stenting in Humans Macroscopic, Histological, and Immunohistochemical Analyses,” Circulation, 98(3), pp. 224–233. [CrossRef]
Rachev, A., Stergiopulos, N., and Meister, J., 1998, “A Model for Geometric and Mechanical Adaptation of Arteries to Sustained Hypertension,” ASME J. Biomech. Eng., 120(1), pp. 9–17. [CrossRef]
Taber, L., 1998, “A Model for Aortic Growth Based on Fluid Shear and Fiber Stresses,” ASME J. Biomech. Eng., 120(3), pp. 348–354. [CrossRef]
Alford, P., Humphrey, J., and Taber, L., 2008, “Growth and Remodeling in a Thick-Walled Artery Model: Effects of Spatial Variations in Wall Constituents,” Biomech. Model. Mechanobiol., 7(4), pp. 245–262. [CrossRef]
Humphrey, J. D., 2001, “Stress, Strain, and Mechanotransduction in Cells,” ASME J. Biomech. Eng., 123(6), pp. 638–641. [CrossRef]
Gleason, R., and Humphrey, J. D., 2005, “A Mixture Model of Arterial Growth and Remodeling in Hypertension: Altered Muscle Tone and Tissue Turnover,” J. Vasc. Res., 41(4), pp. 352–363. [CrossRef]
Javier, R., Goicolea, J., and Felipe, G., 2007, “A Volumetric Model for Growth of Arterial Walls With Arbitrary Geometry and Loads,” J. Biomech., 40(5), pp. 961–971. [CrossRef]

Figures

Grahic Jump Location
Fig. 1.

The computational model for artery remodeling

Grahic Jump Location
Fig. 2

The remodeling process of restenosis formation induced by stent, including the first to eighth phase (from left to right and up to down)

Grahic Jump Location
Fig. 3

The comparison of von Mises stress of the artery before (left) and after (right) the remodeling process

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