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Research Papers

Silicone-Based Tissue-Mimicking Phantom for Needle Insertion Simulation

[+] Author and Article Information
Yancheng Wang

Department of Mechanical Engineering,
University of Michigan,
Ann Arbor, MI 48109
e-mail: yancwang@umich.edu

Bruce L. Tai

Department of Mechanical Engineering,
University of Michigan,
Ann Arbor, MI 48109
e-mail: ljtai@umich.edu

Hongwei Yu

Department of Mechanical Engineering,
University of Michigan,
Ann Arbor, MI 48109
e-mail: yhongwei@umich.edu

Albert J. Shih

Department of Mechanical Engineering,
University of Michigan,
Ann Arbor, MI 48109;
Department of Biomedical Engineering,
University of Michigan,
Ann Arbor, MI 48109
e-mail: shiha@umich.edu

Manuscript received February 27, 2013; final manuscript received January 6, 2014; published online March 7, 2014. Assoc. Editor: Carl A. Nelson.

J. Med. Devices 8(2), 021001 (Mar 07, 2014) (7 pages) Paper No: MED-13-1020; doi: 10.1115/1.4026508 History: Received February 27, 2013; Revised January 06, 2014

Silicone-based tissue-mimicking phantom is widely used as a surrogate of tissue for clinical simulators, allowing clinicians to practice medical procedures and researchers to study the performance of medical devices. This study investigates using the mineral oil in room-temperature vulcanizing silicone to create the desired mechanical properties and needle insertion characteristics of a tissue-mimicking phantom. Silicone samples mixed with 0, 20, 30, and 40 wt. % mineral oil were fabricated for indentation and needle insertion tests and compared to four types of porcine tissues (liver, muscle with the fiber perpendicular or parallel to the needle, and fat). The results demonstrated that the elastic modulus and needle insertion force of the phantom both decrease with an increasing concentration of mineral oil. Use of the mineral oil in silicone could effectively tailor the elastic modulus and needle insertion force to mimic the soft tissue. The silicone mixed with 40 wt. % mineral oil was found to be the best tissue-mimicking phantom and can be utilized for needle-based medical procedures.

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References

Coles, T. R., Meglan, D., and John, N. W., 2011, “The Role of Haptics in Medical Training Simulators: A Survey of the State of the Art,” IEEE Trans. Haptics, 4(1), pp. 51–66. [CrossRef]
Liu, A., Tendick, F., Cleary, K., and Kaufmann, C., 2003, “A Survey of Surgical Simulation: Applications, Technology, and Education,” Presence: Teleop. Virtual Environ., 12(6), pp. 599–614. [CrossRef]
Zell, K., Sperl, J. I., Vogel, M. W., Niessner, R., and Haisch, C., 2007, “Acoustical Properties of Selected Tissue Phantom Materials for Ultrasound Imaging,” Phys. Med. Biol., 52(20), pp. 475–484. [CrossRef]
Spirou, G. M., Oraevsky, A. A., Vitkin, I. A., and Whelan, W. M., 2005, “Optical and Acoustic Properties at 1064 nm of Polyvinyl Chloride-Plastisol for Use as a Tissue Phantom in Biomedical Optoacoustics,” Phys. Med. Biol., 50(14), pp. 141–153. [CrossRef]
Madsen, E. L., Frank, G. R., Krouskop, T. A., Varghese, T., Kallel, F., and Ophir, J., 2003, “Tissue-Mimicking Oil-in-Gelatin Dispersions for Use in Heterogeneous Elastography Phantoms,” Ultrason. Imaging, 25(1), pp. 17–38. [CrossRef]
Hall, T. J., Bilgen, M., Insana, M. F., and Krouskop, T. A., 1997, “Phantom Materials for Elastography,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 44(6), pp. 1355–1365. [CrossRef]
Giavasis, I., Harvey, L. M., and McNeil, B., 2000, “Gellan Gum,” Crit. Rev. Biotechnol., 20, pp. 177–211. [CrossRef]
Chen, R. K. and Shih, A. J., 2013, “Multi-Modality Gellan Gum-Based Tissue Mimicking Phantom With Targeted Mechanical, Electrical, and Thermal Properties,” Phys. Med. Biol., 58, pp. 5511–5525. [CrossRef]
Hungr, N., Long, J.-A., Beix, V., and Troccaz, J., 2012, “A Realistic Deformation Prostate Phantom for Multimodal Imaging and Needle-Insertion Procedures,” Med. Phys., 39(4), pp. 2031–2041. [CrossRef]
Pogue, B. W., and Patterson, M. S., 2006, “Review of Tissue Simulating Phantoms for Optical Spectroscopy, Imaging and Dosimetry,” J. Biomed. Opt., 11(4), p. 041102. [CrossRef]
Gao, Z., Lister, K., and Desai, J. P., 2010, “Constitution Modeling of Liver Tissue: Experiment and Theory,” Ann. Biomed. Eng., 38(2), pp. 505–516. [CrossRef]
Lu, M. H., Yu, W. N., Huang, Q. H., Huang, Y. P., and Zheng, Y. P., 2009, “A Hand-Held Indentation System for the Assessment of Mechanical Properties of Soft Tissues In Vivo,” IEEE Trans. Instrum. Meas., 58(9), pp. 3079–3085. [CrossRef]
Madsen, E. L., Frank, G. R., Krouskop, T. A., Varghese, T., Kallel, F., and Ophir, J., 2003, “Tissue-Mimicking Oil-in-Gelatin Dispersions for Use in Heterogeneous Elastrography Phantoms,” Ultrason. Imaging, 25, pp. 17–38. [CrossRef]
Abolhassani, N., Patel, R., and Moallem, M., 2007, “Needle Insertion Into Soft Tissue: A Survey,” Med. Eng. Phys., 29(4), pp. 413–431. [CrossRef]
van Gerwen, D. J., Dankelman, J., and van den Dobbelsteen, J. J., 2012, “Needle-Tissue Interaction Forces—A Survey of Experimental Data,” Med. Eng. Phys., 34, pp. 665–680. [CrossRef]
Okamura, A. M., 2004, “Force Modeling for Needle Insertion Into Soft Tissue,” IEEE Trans. Biomed. Eng., 51, pp. 1708–1713. [CrossRef]
Moore, J. Z., Malukhin, K., Shih, A. J., and Ehmann, K. F., 2011, “Hollow Needle Tissue Insertion Force Model,” CIRP Ann., 60, pp. 157–160. [CrossRef]
Moore, J. Z., McLaughlin, P. W., and Shih, A. J., 2012, “Novel Needle Cutting Edge Geometry for End-Cut Biopsy,” Med. Phys., 39, pp. 99–108. [CrossRef]
Wang, Y. C., Tai, B. L., Chen, R. K., and Shih, A. J., 2013, “The Needle With Lancet Point—Geometry for Needle Tip Grinding and Tissue Insertion Force,” ASME J. Manuf. Sci. Eng., 135(4), p. 041010. [CrossRef]
Wang, Y. C., Chen, R. K., Tai, B. L., and Shih, A. J., 2013, “Optimal Needle Design for Minimal Insertion Force and Bevel Length,” Med. Eng. Phys. (submitted).
Finocchio, D., J., 2005, “Material Safety Data Sheet Dragon Skin and Dragon Skin Q,” Smooth-On Inc., Easton PA, http://apps.risd.edu/envirohealth_msds/dragonskin.pdf
Tadesse, Y., Moore, D., Thayer, N., and Priya, S., 2009, “Silicone Based Artificial Skin for Humanoid Facial Expressions,” Proc. SPIE, 7287, p. 728709. [CrossRef]
Egorov, V., Tsyuryupa, S., Kanilo, S., Kogit, M., and Sarvazyan, A., 2008, “Soft Tissue Elastometer,” Med. Eng. Phys., 30, pp. 206–212. [CrossRef]
Hideaki, I., and Yuuki, Y., 2006, “Measurement of Silicone Rubber Using Impedance Change of a Quartz-Crystal Tuning-Fork Tactile Sensor,” Jpn. J. Appl. Phys., 45, pp. 4643–4646. [CrossRef]
Chen, E. J., Novakofski, J., Jenkins, W. K., and O'Brien, W. D., 1996, “Young's Modulus Measurement of Soft Tissues With Application to Elasticity Imaging,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 43, pp. 191–194. [CrossRef]
ASTM Standard D2240-05, 2003, “Standard Test Method for Rubber Property-Durometer Hardness,” ASTM International, West Conshohocken, PA.
Kobayashi, Y., Sato, T., and Fujie, M. G., 2009, “Modeling of Friction Force Based on Relative Velocity Between Liver Tissue and Needle for Needle Insertion Simulation,” Annual International Conference of the IEEE, Engineering in Medicine and Biology Society (EMBC 2009), Minneapolis, MN, September 3–6, pp. 5274-5278. [CrossRef]
Kataoka, H., Washio, T., Chinzei, K., Mizuhara, K., Simone, C., and Okamura, A. M., 2002, “Measurement of the Tip and Friction Force Acting on a Needle During Penetration,” Proceedings of the 5th Interational Medical Image Computing and Computer-Assisted Intervention Conference (MICCAI 2002), Tokyo, September 25–28, pp. 216–223. [CrossRef]

Figures

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Fig. 1

Molding of the TM silicone phantom: (a) plastic mold, (b) mold internal geometry, (c) silicone phantom in the mold, and (d) a silicone phantom specimen after molding

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Fig. 2

Indentation test for elastic modulus measurements: (a) before indenter compression, (b) close up view of the indenter of the durometer, and (c) after indenter compression

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Fig. 3

Needle insertion test experimental setup: (a) overview, (b) close up view of the trocar tip and the silicone specimen, and (c) shape of the specimen holder and specimen

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Fig. 4

Test specimens in the holder (a) muscle perpendicular to the fiber, (b) silicone specimen, and (c) schematic view of the six needle insertion positions in the specimen holder

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Fig. 5

Needle insertion forces for silicone with 0% mineral oil

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Fig. 6

Needle insertion force versus time for four silicone specimen with: (a) 0, (b) 20, (c) 30, and (d) 40 wt. % mineral oil

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Fig. 7

Needle insertion force versus time for four types of porcine soft tissue: (a) fat, (b) muscle perpendicular to the fiber, (c) muscle parallel to the fiber, and (d) liver

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Fig. 8

Average and standard deviation of the force components of (a) silicone specimens, and (b) porcine ex vivo tissues for six repeated needle insertion

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Fig. 9

The degradation of (a) forward, and (b) backward friction forces throughout five phases for six repeated needle insertion

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