Sterilization is a vital component of the manufacturing process for any medical device. However, some sterilization techniques may alter device properties. While it is known that electron beam sterilization can change the mechanical properties of solid polymethylmethacrylate (PMMA) constructs, its effect on porous PMMA has not been explored. Therefore, porous PMMA space maintainer constructs designed for the treatment of craniofacial bone defects were sterilized at dosages of 30 kGy and 40 kGy. Electron beam sterilization was shown to increase the compressive properties of porous PMMA space maintainer devices.