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Technical Brief

Effects of Electron Beam Sterilization on Mechanical Properties of a Porous Polymethylmethacrylate Space Maintenance Device

[+] Author and Article Information
Alexander M. Tatara

Department of Bioengineering,
Rice University,
P.O. Box 1892,
Houston, TX 77005
e-mail: Tatara@rice.edu

Sarita R. Shah

Department of Bioengineering,
Rice University,
P.O. Box 1892,
Houston, TX 77005
e-mail: Srs8@rice.edu

Mohammad Sotoudeh

Synthasome, Inc.,
3030 Bunker Hill Street, Suite 308,
San Diego, CA 92019
e-mail: MohammadSotoudeh@synthasome.com

Allan M. Henslee

Department of Bioengineering,
Rice University,
P.O. Box 1892,
Houston, TX 77005
e-mail: Allan.henslee@gmail.com

Mark E. Wong

The University of Texas School of Dentistry at Houston,
6516 MD Anderson Boulevard,
Houston, TX 77030
e-mail: Mark.E.Wong@uth.tmc.edu

Anthony Ratcliffe

Synthasome, Inc.,
3030 Bunker Hill Street, Suite 308,
San Diego, CA 92019
e-mail: AnthonyRatcliffe@synthasome.com

F. Kurtis Kasper

Department of Bioengineering,
Rice University,
P.O. Box 1892,
Houston, TX 77005
e-mail: Kasper@rice.edu

Antonios G. Mikos

Department of Bioengineering,
Rice University,
P.O. Box 1892,
Houston, TX 77005
e-mail: Mikos@rice.edu

1Corresponding author.

Manuscript received March 13, 2014; final manuscript received January 23, 2015; published online April 24, 2015. Assoc. Editor: Rosaire Mongrain.

J. Med. Devices 9(2), 024501 (Jun 01, 2015) (4 pages) Paper No: MED-14-1145; doi: 10.1115/1.4029707 History: Received March 13, 2014; Revised January 23, 2015; Online April 24, 2015

Sterilization is a vital component of the manufacturing process for any medical device. However, some sterilization techniques may alter device properties. While it is known that electron beam sterilization can change the mechanical properties of solid polymethylmethacrylate (PMMA) constructs, its effect on porous PMMA has not been explored. Therefore, porous PMMA space maintainer constructs designed for the treatment of craniofacial bone defects were sterilized at dosages of 30 kGy and 40 kGy. Electron beam sterilization was shown to increase the compressive properties of porous PMMA space maintainer devices.

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References

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Figures

Grahic Jump Location
Fig. 1

Specimens utilized for mechanical analysis. (a) Cylindrical specimens before (A) and after (B) compressive testing. (b) Rectangular specimens for 4 point bending after failure.

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Fig. 2

Representative stress–strain curves (0 kGy—short dash, 30 kGy—long dash, and 40 kGy—solid line) from compressive testing

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Fig. 3

Representative microcomputed tomography binary images of porous PMMA constructs (cross section). Specimens had a cross-sectional diameter of 10 mm. Black color represents void space.

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