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Technical Brief

Proof-of-Concept Prototype for Noninvasive Intracranial Pressure Monitoring Using Ocular Hemodynamics Under Applied Force

[+] Author and Article Information
Tyler Ketchem

Department of Mechanical & Materials Engineering,
University of Nebraska–Lincoln,
W342 Nebraska Hall,
Lincoln, NE 68588-0526
e-mail: tketchem@hotmail.com

Max Twedt

Department of Biological Systems Engineering,
University of Nebraska–Lincoln,
223 Chase Hall,
Lincoln, NE 68583
e-mail: mhtwedt@gmail.com

Darrin Lim

Department of Biomedical Engineering,
Duke University,
Box 98651,
Durham, NC 27708
e-mail: darrin.lim@duke.edu

Greg Bashford

Department of Biological Systems Engineering,
University of Nebraska–Lincoln,
230 L.W. Chase Hall,
Lincoln, NE 68583
e-mail: gbashford2@unl.edu

Jeff A. Hawks

Mem. ASME
Mechanical & Materials Engineering Department,
University of Nebraska–Lincoln,
W342 Nebraska Hall,
P.O. Box 880526,
Lincoln, NE 68588-0526
e-mail: jhawks2@unl.edu

1Corresponding author.

Manuscript received March 25, 2014; final manuscript received January 31, 2015; published online April 24, 2015. Assoc. Editor: Rosaire Mongrain.

J. Med. Devices 9(2), 024502 (Jun 01, 2015) (4 pages) Paper No: MED-14-1155; doi: 10.1115/1.4029810 History: Received March 25, 2014; Revised January 31, 2015; Online April 24, 2015

Studies have suggested that elevated cerebrospinal fluid (CSF) pressure can have a damaging effect on the optic nerve and visual acuity. There is need for a noninvasive CSF pressure measurement technique. A portable device for noninvasive intracranial pressure (ICP) monitoring would have a significant impact on clinical care. A proof-of-concept prototype is used to test the feasibility of a technique for monitoring ICP changes. The proposed methodology utilizes transcranial Doppler ultrasonography to monitor blood flow through the ophthalmic and central retinal arteries while forces are applied to the cornea by a controlled actuator. Control algorithms for the device were developed and tested using an integrated experimental platform. Preliminary results using tissue-mimicking materials show the ability to differentiate between materials of differing stiffness that simulates different levels of ICP. These experiments are an initial step toward a handheld noninvasive ICP monitoring device.

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Figures

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Fig. 1

Initial experimental data collection platform for testing flow dynamics under varying stress and strain rates

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Fig. 2

Experimental results for mean flow velocity with respect to increasing applied force on the Ecoflex 10 silicone

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Fig. 3

Experimental results for mean flow velocity with respect to increasing applied force on the Ecoflex 20 silicone

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Fig. 4

Handheld prototype for future in vivo testing with porcine animals and human subjects

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