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Special Section Technical Briefs

Interspecies Differences in Electromechanical and Histological Characteristics of Human and Swine Esophagus1

[+] Author and Article Information
Ashish Singal

Department of Biomedical Engineering,
University of Minnesota,
Minneapolis, MN 55455;
Department of Surgery,
University of Minnesota,
Minneapolis, MN 55455

Carrie Ronstrom

Medical School,
University of Minnesota,
Minneapolis, MN 55455

Charles L. Soule

Department of Surgery,
University of Minnesota,
Minneapolis, MN 55455

Anthony Weinhaus

Integrative Biology & Physiology,
University of Minnesota,
Minneapolis, MN 55455

Paul A. Iaizzo

Department of Biomedical Engineering,
University of Minnesota,
Minneapolis, MN 55455;
Department of Surgery,
University of Minnesota,
Minneapolis, MN 55455;
Integrative Biology & Physiology,
University of Minnesota,
Minneapolis, MN 55455;
Institute for Engineering in Medicine,
University of Minnesota,
Minneapolis, MN 55455

Accepted and presented at The Design of Medical Devices Conference (DMD2015), April 13-16, 2015, Minneapolis, MN, USA.

Manuscript received March 3, 2015; final manuscript received March 16, 2015; published online April 24, 2015. Editor: Arthur Erdman.

J. Med. Devices 9(2), 020903 (Jun 01, 2015) (3 pages) Paper No: MED-15-1038; doi: 10.1115/1.4030113 History: Received March 03, 2015; Revised March 16, 2015; Online April 24, 2015

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References

Watanabe, M., Sekine, K., Hori, Y., Shiraishi, Y., Maeda, T., Honma, D., Miyata, G., Saijo, Y., and Yambe, T., 2005, “Artificial Esophagus With Peristaltic Movement,” ASAIO J., 51(2), pp. 158–161. [CrossRef] [PubMed]
Singal, A., Soule, C. L., Ballard, J. R., Cressman, E. N., and Iaizzo, P. A., 2014, “Physiological Tissue Response to Various Ablative Modalities,” ASME J. Med. Devices, 8(2), p. 020906. [CrossRef]
Meyer, G. W., Austin, R. M., Brady, C. E., III, and Castell, D. O., 1986, “Muscle Anatomy of the Human Esophagus,” J. Clin. Gastroenterol., 8(2), pp. 131–134. [CrossRef] [PubMed]
Yazaki, E1., and Sifrim, D., 2012, “Anatomy and Physiology of the Esophageal Body,” Dis. Esophagus, 25(4), pp. 292–298. [CrossRef] [PubMed]

Figures

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Fig. 1

Human (a) and swine (b) esophagi were dissected in five segments as shown. Swine esophagus is dissected to reflect the muscularis and squamous epithelium layers.

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Fig. 2

A representative example of electromechanical response of swine and human esophageal muscle bundle

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Fig. 3

Varying electromechanical response of human esophagus based on where it is stimulated along its length

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Fig. 4

A 20× image of human superior esophagus. Both outer longitudinal and inner circular muscularis layers are shown composed of skeletal muscle fibers discernible by the striations and the location of the nuclei on the periphery of the cells.

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Fig. 5

A 20× image of middle section of the human esophagus. Both outer longitudinal and inner circular muscularis layers are shown composed of smooth muscle fibers discernible by the spindle shaped nuclei and their location toward the center of the cell.

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Fig. 6

A 20× image of human inferior esophagus. Both outer longitudinal and inner circular muscularis layers are shown composed of smooth muscle fibers discernible by the spindle shaped nuclei and their location toward the center of the cell.

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