Special Section Technical Briefs

Peregrine System™ Infusion Catheter for Perivascular Renal Denervation1

[+] Author and Article Information
David R. Fischell

Ablative Solutions, Inc.,
Fair Haven, NJ 07704

Tim A. Fischell

Ablative Solutions, Inc.,
Kalamazoo, MI 49007

Vartan Ghazarossian

Ablative Solutions, Inc.,
Menlo Park, CA 94025

Accepted and presented at The Design of Medical Devices Conference (DMD2015), April 13-16, 2015, Minneapolis, MN, USA.

Manuscript received March 3, 2015; final manuscript received March 16, 2015; published online April 24, 2015. Editor: Arthur Erdman.

J. Med. Devices 9(2), 020905 (Jun 01, 2015) (2 pages) Paper No: MED-15-1040; doi: 10.1115/1.4030114 History: Received March 03, 2015; Revised March 16, 2015; Online April 24, 2015

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Copyright © 2015 by ASME
Topics: Catheters , Kidney , Ethanol
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Berne, R. M., 1952, “Hemodynamics and Sodium Excretion of Denervated Kidney in Anesthetized and Unanesthetized Dog,” Am. J. Physiol., 171(1), pp. 148–158. [PubMed]
Bhatt, D. L., Kandzari, D. E., O'Neill, W. W., D'Agostino, R., Flack, J. M., Katzen, B. T., Leon, M. B., Liu, M., Mauri, L., Negoita, M., Cohen, S. A., Oparil, S., Rocha-Singh, K., Townsend, R. R., Bakris, G. L., and SYMPLICITY HTN-3 Investigators, 2014, “A Controlled Trial of Renal Denervation for Resistant Hypertension,” N. Engl. J. Med., 370(15), pp. 1393–1401. [CrossRef] [PubMed]
Fischell, T. A., Vega, F., Raju, N., Johnson, E. T., Kent, D. J., Ragland, R. R., Fischell, D. R., Almany, S. L., and Ghazarossian, V. E., 2013, “Ethanol-Mediated Perivascular Renal Sympathetic Denervation: Preclinical Validation of Safety and Efficacy in a Porcine Model,” EuroIntervention, 9(1), pp. 140–147. [CrossRef] [PubMed]


Grahic Jump Location
Fig. 1

Sequence of use for the Peregrine™ to perform perivascular renal denervation

Grahic Jump Location
Fig. 2

Angiographic visualization of the distal portion of the PeregrineTM renal denervation catheter during the first in man clinical study

Grahic Jump Location
Fig. 3

First in man results. Mean blood pressure before and after perivascular renal denervation (N = 17).



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