Special Section Technical Briefs

Methodologies for Pulmonary Artery Pressure Waveform and Wave Reflection Analysis in Patients With Pulmonary Hypertension1

[+] Author and Article Information
Ashish Singal, Sheiphali Gandhi, Marc Pritzker, Thenappan Thenappan

Department of Cardiovascular Medicine,
University of Minnesota,
Minneapolis, MN 55455

Accepted and presented at The Design of Medical Devices Conference (DMD2015), April 13-16, 2015, Minneapolis, MN, USA.

Manuscript received March 3, 2015; final manuscript received March 16, 2015; published online April 24, 2015. Editor: Arthur Erdman.

J. Med. Devices 9(2), 020906 (Jun 01, 2015) (3 pages) Paper No: MED-15-1041; doi: 10.1115/1.4030115 History: Received March 03, 2015; Revised March 16, 2015; Online April 24, 2015

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Castelain, V., Hervé, P., Lecarpentier, Y., Duroux, P., Simonneau, G., and Chemla, D., 2001, “Pulmonary Artery Pulse Pressure and Wave Reflection in Chronic Pulmonary Thromboembolism and Primary Pulmonary Hypertension,” J. Am. Coll. Cardiol., 37(4), pp. 1085–1092. [CrossRef] [PubMed]
Murgo, J. P., Westerhof, N., Giolma, J. P., and Altobelli, S. A., 1980, “Aortic Input Impedance in Normal Man: Relationship to Pressure Wave Forms,” Circulation, 62(1), pp. 105–116. [CrossRef] [PubMed]


Grahic Jump Location
Fig. 1

A representative example of time averaged PA waveform illustrating the key landmark points that were used to calculate waveform parameters

Grahic Jump Location
Fig. 2

PA pressure tracings in two cases showing the inflection point occurrence before and after the peak pulse pressure. Inflection point and calculation of AI in both cases are indicated.

Grahic Jump Location
Fig. 3

PA waveform superimposed with dP/dt indicating the local-minima and/or zero-crossings in each case

Grahic Jump Location
Fig. 4

Correlation between augmentation pressure (AP) and augmentation index (AI) (n = 842)

Grahic Jump Location
Fig. 5

Correlation between inflection time (IT) and augmentation index (AI) (n = 842)



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