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Special Section Technical Briefs

Effect of Turbulent Flow on Hemolysis Utilizing a Turbulent Free Jet1

[+] Author and Article Information
Megan A. Stauffer, John D. Reibson, Eric E. Yeager, Choon-Sik Jhun, Raymond K. Newswanger, Joshua P. Cysyk, William J. Weiss, Gerson Rosenberg

Department of Surgery,
Penn State College of Medicine,
Hershey, PA 17033

Accepted and presented at The Design of Medical Devices Conference (DMD2015), April 13-16, 2015, Minneapolis, MN, USA.

Manuscript received March 3, 2015; final manuscript received March 16, 2015; published online April 24, 2015. Editor: Arthur Erdman.

J. Med. Devices 9(2), 020908 (Jun 01, 2015) (2 pages) Paper No: MED-15-1043; doi: 10.1115/1.4030117 History: Received March 03, 2015; Revised March 16, 2015; Online April 24, 2015

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Topics: Turbulence
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References

Giersiepen, M., Wurzinger, L. J., Opitz, R., and Reul, H., 1990, “Estimation of Shear Stress-Related Blood Damage in Heart Valve Prostheses—In Vitro Comparison of 25 Aortic Valves,” Int. J. Artif. Organs, 13(5), pp. 300–306. [PubMed]
Jones, S. A., 1995, “A Relationship Between Reynolds Stresses and Viscous Dissipation: Implications to Red Cell Damage,” Ann. Biomed. Eng., 23(1), pp. 21–28. [CrossRef] [PubMed]
Kameneva, M. V., Burgreen, G. W., Kono, K., Repko, B., Antaki, J. F., and Umezu, M., 2004, “Effects of Turbulent Stresses Upon Mechanical Hemolysis: Experimental and Computational Analysis,” ASAIO J., 50(5), pp. 418–423. [CrossRef] [PubMed]
Quinlan, N. J., and Dooley, P. N., 2007, “Models of Flow-Induced Loading on Blood Cells in Laminar and Turbulent Flow, With Application to Cardiovascular Device Flow,” Ann. Biomed. Eng., 35(8), pp. 1347–1356. [CrossRef] [PubMed]
Sallam, A. M., and Hwang, N. H., 1983, “Human Red Blood Cell Hemolysis in a Turbulent Shear Flow: Contribution of Reynolds Shear Stresses,” Biorheology, 21(6), pp. 783–797.
Forstrom, R. J., 1969, “A New Measure of Erythrocyte Membrane Strength: The Jet Fragility Test,” Ph.D. thesis, University of Minnesota, Minneapolis, MN.
Liu, J. S., Lu, P. C., and Chu, S. H., 2000, “Turbulence Characteristics Downstream of Bileaflet Aortic Valve Prostheses,” ASME J. Biomech. Eng., 122(2), pp. 118–124. [CrossRef]
Antonia, R. A., Satyaprakash, B. R., and Hussain, A. K. M. F., 1980, “Measurements of Dissipation Rate and Some Other Characteristics of Turbulent Plane and Circular Jets,” Phys. Fluids, 23(4), pp. 695–700. [CrossRef]
Kolmogorov, A. N., 1941, “The Local Structure of Turbulence in Incompressible Viscous Fluid for Very Large Reynolds Numbers,” Dokl. Akad. Nauk SSSR, 30(4), pp. 9–13. http://www.jstor.org/stable/51980
Harboe, M., 1959, “A Method for Determination of Hemoglobin in Plasma by Near-Ultraviolet Spectrophotometry,” Scand. J. Clin. Lab. Invest., 11(1), pp. 66–70. [CrossRef] [PubMed]

Figures

Grahic Jump Location
Fig. 1

Submerged free jet chamber with jet entrance nozzle, A, blood injection needle, B, and sample aspirator, C

Grahic Jump Location
Fig. 2

Blood entering the free jet with the aspirator at (x/de = 6.5, y/re = 1.2)

Grahic Jump Location
Fig. 3

Average Hp with standard deviation and sample size per Re

Grahic Jump Location
Fig. 4

Turbulence energy dissipation (ε) from CFD for Re = 20,000 (top) and Re = 40,000 (bottom)

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