Special Section Technical Briefs

A Reproducible Model of a Chronic Partial Occlusion: A Cylindrical Bone Marrow Allograft Implanted in the Porcine Coronary and Peripheral Vasculature1

[+] Author and Article Information
Michael Frie, Michael Jorgenson, Mark E. Smith, Michael Conforti

American Preclinical Services,
Minneapolis, MN 55433

Accepted and presented at The Design of Medical Devices Conference (DMD2015), April 13-16, 2015, Minneapolis, MN, USA.

Manuscript received March 3, 2015; final manuscript received March 23, 2015; published online April 24, 2015. Editor: Arthur Erdman.

J. Med. Devices 9(2), 020909 (Jun 01, 2015) (3 pages) Paper No: MED-15-1044; doi: 10.1115/1.4030187 History: Received March 03, 2015; Revised March 23, 2015; Online April 24, 2015

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Topics: Bone
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Grahic Jump Location
Fig. 1

This image illustrates the actual size and appearance of the bone marrow cylinders and shows the range in size from 2 to 5 mm diameter; all were prepared with 1–2 mm lumens

Grahic Jump Location
Fig. 2

A typical plug is loaded into a 9Fr guide catheter or onto a 0.035 in. guide wire and tracked to its intended implant location within the target artery

Grahic Jump Location
Fig. 3

Postimplant angiograms of a bone plug implanted in the LAD coronary artery (left) and right internal femoral artery (right)

Grahic Jump Location
Fig. 4

Followup angiographic images of the implanted bone plug are shown in the coronary (left) and peripheral vasculature (right). The bone plugs were typically implanted for 4–14 days.

Grahic Jump Location
Fig. 5

Optical computed tomography (OCT, left) and Intravascular ultrasound (IVUS, right) images of the implanted plug acquired prior to dilation with a balloon catheter

Grahic Jump Location
Fig. 6

Longitudinal OCT imaging of a femoral artery after plug deployment

Grahic Jump Location
Fig. 7

Bone plug placed in the LAD of an animal terminated at 14 days post-implant. The lumen of the bone plug was over 95% patent having a thin rim of fibrin thrombus with entrapped erythrocytes coating the periphery.

Grahic Jump Location
Fig. 8

Bone plug implanted in the right internal iliac (left: pentachrome stain, right: von Kossa). There was positive staining of the bony trabeculae located in ½ of the lumen directly adjacent to the artery wall.



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