Special Section Technical Briefs

Recording Neuronal Spike Activity During Transcranial Direct Current Stimulation1

[+] Author and Article Information
Nathaniel J. Faber, Filippo Agnesi, Matthew D. Johnson

Department of Biomedical Engineering,
University of Minnesota,
Minneapolis, MN 55455

Accepted and presented at The Design of Medical Devices Conference (DMD2015), April 13-16, 2015, Minneapolis, MN, USA.

Manuscript received March 3, 2015; final manuscript received March 17, 2015; published online April 24, 2015. Editor: Arthur Erdman.

J. Med. Devices 9(2), 020948 (Jun 01, 2015) (2 pages) Paper No: MED-15-1054; doi: 10.1115/1.4030127 History: Received March 03, 2015; Revised March 17, 2015; Online April 24, 2015

First Page Preview

View Large
First page PDF preview
Copyright © 2015 by ASME
Your Session has timed out. Please sign back in to continue.


Nitsche, M. A., and Paulus, W., 2000, “Excitability Changes Induced in the Human Motor Cortex by Weak Transcranial Direct Current Stimulation,” J. Physiol., 527(Pt 3), pp. 633–639. [CrossRef] [PubMed]
Priori, A., Berardelli, A., Rona, S., Accornero, N., and Manfredi, M., 1998, “Polarization of the Human Motor Cortex Through the Scalp,” Neuroreport, 9(10), pp. 2257–2260. [CrossRef] [PubMed]
Nitsche, M. A., Schauenburg, A., Lang, N., Liebetanz, D., Exner, C., Paulus, W., and Tergau, F., 2003, “Facilitation of Implicit Motor Learning by Weak Transcranial Direct Current Stimulation of the Primary Motor Cortex in the Human,” J. Cognit. Neurosci., 15(4), pp. 619–626. [CrossRef]
Gladwin, T. E., den Uyl, T. E., Fregni, F. F., and Wiers, R. W., 2012, “Enhancement of Selective Attention by tDCS: Interaction With Interference in a Sternberg Task,” Neurosci. Lett., 512(1), pp. 33–37. [CrossRef] [PubMed]
Fregni, F., Boggio, P. S., Mansur, C. G., Wagner, T., Ferreira, M. J., Lima, M. C., Rigonatti, S. P., Marcolin, M. A., Freedman, S. D., Nitsche, M. A., and Pascual-Leone, A., 2005, “Transcranial Direct Current Stimulation of the Unaffected Hemisphere in Stroke Patients,” Neuroreport, 16(14), pp. 1551–1555. [CrossRef] [PubMed]
Benninger, D. H., Lomarev, M., Lopez, G., Wassermann, E. M., Li, X., Considine, E., and Hallett, M., 2010, “Transcranial Direct Current Stimulation for the Treatment of Parkinson’s Disease,” J. Neurol. Neurosurg. Psychiatry, 81(10), pp. 1105–1111. [CrossRef] [PubMed]
Fregni, F., Boggio, P. S., Santos, M. C., Lima, M., Vieira, A. L., Rigonatti, S. P., Silva, M. T., Barbosa, E. R., Nitsche, M. A., and Pascual-Leone, A., 2006, “Noninvasive Cortical Stimulation With Transcranial Direct Current Stimulation in Parkinson’s Disease,” Mov. Disord., 21(10), pp. 1693–1702. [CrossRef] [PubMed]
Brunoni, A. R., Ferrucci, R., Bortolomasi, M., Vergari, M., Tadini, L., Boggio, P. S., Giacopuzzi, M., Barbieri, S., and Priori, A., 2011, “Transcranial Direct Current Stimulation (tDCS) in Unipolar vs. Bipolar Depressive Disorder,” Prog. Neuropsychopharmacol. Biol. Psychiatry, 35(1), pp. 96–101. [CrossRef] [PubMed]
Boggio, P. S., Sultani, N., Fecteau, S., Merabet, L., Mecca, T., Pascual-Leone, A., Basaglia, A., and Fregni, F., 2008, “Prefrontal Cortex Modulation Using Transcranial DC Stimulation Reduces Alcohol Craving: A Double-Blind, Sham-Controlled Study,” Drug Alcohol Depend., 92(1–3), pp. 55–60. [CrossRef] [PubMed]
Fregni, F., Liguori, P., Fecteau, S., Nitsche, M. A., Pascual-Leone, A., and Boggio, P. S., 2008, “Cortical Stimulation of the Prefrontal Cortex With Transcranial Direct Current Stimulation Reduces Cue-Provoked Smoking Craving: A Randomized, Sham-Controlled Study,” J. Clin. Psychiatry, 69(1), pp. 32–40. [CrossRef] [PubMed]
Nitsche, M. A., and Paulus, W., 2001, “Sustained Excitability Elevations Induced by Transcranial DC Motor Cortex Stimulation in Humans,” Neurology, 57(10), pp. 1899–1901. [CrossRef] [PubMed]
Nitsche, M. A., Fricke, K., Henschke, U., Schlitterlau, A., Liebetanz, D., Lang, N., Henning, S., Tergau, F., and Paulus, W., 2003, “Pharmacological Modulation of Cortical Excitability Shifts Induced by Transcranial Direct Current Stimulation in Humans,” J. Physiol., 553(Pt 1), pp. 293–301. [CrossRef] [PubMed]
Creutzfeldt, O. D., Fromm, G. H., and Kapp, H., 1962, “Influence of Transcortical DC Currents on Cortical Neuronal Activity,” Exp. Neurol., 5(6), pp. 436–452. [CrossRef] [PubMed]
Datta, A., Zhou, X., Su, Y., Parra, L. C., and Bikson, M., 2013, “Validation of Finite Element Model of Transcranial Electrical Stimulation Using Scalp Potentials: Implications for Clinical Dose,” J. Neural Eng., 10(3), p. 036018. [CrossRef] [PubMed]


Grahic Jump Location
Fig. 1

Schematic representation of the recording setup with 3D-printed plug nested in the cephalic chamber with the recording microelectrode passed into one of the through-ports

Grahic Jump Location
Fig. 2

Top: example of neuronal recording during tDCS. Bottom: mean ± 2 standard deviations of spike waveforms detected before (left), during (middle), and after tDCS (right).



Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In