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Special Section Technical Briefs

Variable-Contact Diffuse Reflectance Spectroscopy in Intravascular Conditions Assessment1

[+] Author and Article Information
Darrin Beekman, Timothy Kowalewski

Department of Mechanical Engineering,
University of Minnesota,
Minneapolis, MN 55455

Accepted and presented at The Design of Medical Devices Conference (DMD2015), April 13–16, 2015, Minneapolis, MN, USA.

Manuscript received March 3, 2015; final manuscript received April 1, 2015; published online July 16, 2015. Editor: Arthur Erdman.

J. Med. Devices 9(3), 030940 (Sep 01, 2015) (2 pages) Paper No: MED-15-1096; doi: 10.1115/1.4030572 History: Received March 03, 2015; Revised April 01, 2015; Online July 16, 2015

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References

CDC, 2013, “Heart Disease Fact Sheet,” Centers for Disease Control and Prevention, Division for Heart Disease and Stroke Prevention, Atlanta, GA, http://www.cdc.gov/dhdsp/data_statistics/fact_sheets/fs_heart_disease.htm
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Blaha, M. J., Dai, S., Ford, E. S., Fox, C. S., and Franco, S., 2014, “Heart Disease and Stroke Statistics—2014 Update. A Report From the American Heart Association,” Circulation, 129(3), pp. e28–e292. [CrossRef] [PubMed]
Badr, S., Ben-Dor, I., Dvir, D., Barbash, I. M., Kitabata, H., Minha, S., Pendyala, L. K., Loh, J. P., Torguson, R., and Pichard, A. D., 2013, “The State of the Excimer Laser for Coronary Intervention in the Drug-Eluting Stent Era,” Cardiovasc. Revasc. Med., 14(2), pp. 93–98. [CrossRef] [PubMed]
Stelzle, F., Tangermann-Gerk, K., Adler, W., Zam, A., Schmidt, M., Douplik, A., and Nkenke, E., 2010, “Diffuse Reflectance Spectroscopy for Optical Soft Tissue Differentiation as Remote Feedback Control for Tissue-Specific Laser Surgery,” Lasers Surg. Med., 42(4), pp. 319–325. [CrossRef] [PubMed]
Rocha, R., Villaverde, A. B., Silveira, L., Jr., Brugnera, A., Jr., Alves, L. P., Munin, E., Rodrigues, K. C., Pasqualucci, C. A., and Pacheco, M. T. T., 2008, “Fluorescence and Reflectance Spectroscopy for Identification of Atherosclerosis in Human Carotid Arteries Using Principal Components Analysis,” Photomed. Laser Surg., 26(4), pp. 329–335. [CrossRef] [PubMed]
Cugmas, B., Bregar, M., Bürmen, M., Pernuš, F., and Likar, B., 2014, “Impact of Contact Pressure-Induced Spectral Changes on Soft-Tissue Classification in Diffuse Reflectance Spectroscopy: Problems and Solutions,” J. Biomed. Opt., 19(3), p. 037002. [CrossRef]
Beekman, D., Bijadi, S., and Kaowalewski, T., 2014, “Real-Time Tissue Differentiation Using Fiber Optic Sensing in Laser Catheters,” ASME J. Med. Devices, 8(3), p. 030934. [CrossRef]

Figures

Grahic Jump Location
Fig. 1

Experimental setup including: (1) an Ocean Optics USB2000+ spectrometer configured for 3.5 nm resolution when using 200 μm optical fibers, (2) a Leica KL 1500 electronic halogen light source, (3) an Ocean Optics QR200-7-VIS-NIR optical fiber probe, (4) an AWS SC-2 kg pocket scale, (5) an Arduino and circuitry to transfer the scale output to the computer via serial, (6) a laptop running a custom C++ console program to control the spectrometer, collect data, and time synchronize the data, (7) a custom adapter connecting the probe to the z-axis translational stage, and (8) an opaque box to hold the tissue samples and fluid on the scale

Grahic Jump Location
Fig. 2

DRS plots of the porcine tissue samples in an air and blood environment. Each curve represents the average DRS data for a specific tissue within the 200–250 gf range. The square pictures are magnified photographs of each tissue type.

Grahic Jump Location
Fig. 3

DRS plots from the porcine fat tissue sample when immersed in a blood environment. Each contour represents the average spectra of all three DRS runs within a specific 10 gf range given in the legend.

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