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Special Section Technical Briefs

Computational Modeling for Analysis and Design of Metallic Biodegradable Stents1

[+] Author and Article Information
Peter E. McHugh, James A. Grogan, Claire Conway, Enda Boland

Biomechanics Research Centre (BMEC),
Biomedical Engineering,
College of Engineering and Informatics,
National University of Ireland, Galway,
Galway, Ireland

Accepted and presented at The Design of Medical Devices Conference (DMD2015), April 13–16, 2015, Minneapolis, MN, USA.

Manuscript received March 3, 2015; final manuscript received March 17, 2015; published online July 16, 2015. Editor: Arthur Erdman.

J. Med. Devices 9(3), 030946 (Sep 01, 2015) (2 pages) Paper No: MED-15-1102; doi: 10.1115/1.4030576 History: Received March 03, 2015; Revised March 17, 2015; Online July 16, 2015

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References

Grogan, J. A., O'Brien, B. J., Leen, S. B., and McHugh, P. E., 2011, “A Corrosion Model for Bioabsorbable Metallic Stents,” Acta Biomater., 7(9), pp. 3523–3533. [CrossRef] [PubMed]
Grogan, J. A., Leen, S. B., and McHugh, P. E., 2013, “Optimizing the Design of a Bioabsorbable Metal Stent Using Computer Simulation Methods,” Biomaterials, 34(33), pp. 8049–8060. [CrossRef] [PubMed]
Patel, N., and Banning, A. P., 2013, “Bioabsorbable Scaffolds for the Treatment of Obstructive Coronary Artery Disease: The Next Revolution in Coronary Intervention?” Heart, 99(17), pp. 1236–1243. [CrossRef] [PubMed]
Haude, M., Erbel, R., Erne, P., Verheye, S., Degen, H., Bose, D., Vermeersch, P., Wijnbergen, I., Weissman, N., Prati, F., Waksman, R., and Koolen, J., 2013, “Safety and Performance of the Drug-Eluting Metal Scaffold (DREAMS) in Patients With De-Novo Coronary Lesions: 12 Month Results of the Prospective, Multicentre, First-In-Man BIOSOLVE-1 Trial,” Lancet, 381(9869), pp. 836–844. [CrossRef] [PubMed]
Shirazi, R. N., Aldabbagh, F., Erxleben, A., Rochev, Y., and McHugh, P., 2014, “Nanomechanical Properties of Poly(Lactic-Co-Glycolic) Acid Film During Degradation,” Acta Biomater., 10(11), pp. 4695–4703. [CrossRef] [PubMed]
Conway, C., Sharif, F., McGarry, J., and McHugh, P., 2012, “A Computational Test-Bed to Assess Coronary Stent Implantation Mechanics Using a Population-Specific Approach,” Cardiovasc. Eng. Technol., 3(4), pp. 374–387. [CrossRef]
Conway, C., McGarry, J. P., and McHugh, P. E., 2014, “Modelling of Atherosclerotic Plaque for Use in a Computational Test-Bed for Stent Angioplasty,” Ann. Biomed. Eng., 42(12), pp. 2425–2439. [CrossRef] [PubMed]
Lally, C., 2004, “An Investigation Into the Influence of Cardiovascular Stent Design on the Development of Restenosis Using the Finite Element Method,” Ph.D. thesis, Trinity College Dublin, Dublin, Ireland.

Figures

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Fig. 1

Stent angioplasty finite element model with artery (outer layers), ghost (inner layers), and stent with generic geometry

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Fig. 2

Percentage stent recoil as a function of Mg mass loss for degradation of a generic Mg stent in an atherosclerotic artery model [1]

Grahic Jump Location
Fig. 3

Strain in the stent for a range of assumed degradation rates and the percentage of tissue remodeled

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