Special Section Technical Briefs

Simulation of Fatigue in Bioprosthetic Heart Valve Biomaterials1

[+] Author and Article Information
Michael S. Sacks

Center for Cardiovascular Simulation,
Institute for Computational Engineering and Sciences,
Department of Biomedical Engineering,
The University of Texas at Austin,
201 East 24th St, Stop C0200,
Austin, TX 78712-1229

Accepted and presented at The Design of Medical Devices Conference (DMD2015), April 13–16, 2015, Minneapolis, MN, USA.

Manuscript received March 3, 2015; final manuscript received March 17, 2015; published online July 16, 2015. Editor: Arthur Erdman.

J. Med. Devices 9(3), 030951 (Sep 01, 2015) (2 pages) Paper No: MED-15-1107; doi: 10.1115/1.4030581 History: Received March 03, 2015; Revised March 17, 2015; Online July 16, 2015

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Fig. 1

A schematic of how EXL—GLUT. After from Cheung and Nimni, Connective Tissue Research, 1982 [5].

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Fig. 2

Overview of the entire model, showing the contributions from the cross-linked fibers and various interaction terms

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Fig. 3

In vitro cyclic loading data for GLUT-fixed bovine pericardium showing (a) the collagen fiber preferred direction groups (PD and XD), and (b)–(e) representative biaxial mechanical testing results, with • representing the 0 × 106 cycle level, □ the 20 × 106 cycle level, and Δ the 50 × 106 cycle level. The XD experienced substantially larger changes in extensibility compared to the PD group, as well a reversal in the direction greatest extensibility. This finding underscores the important role of fiber orientation in BHV issue fatigue behavior [13].

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Fig. 4

(Left) Studies of heart valve permanent set effects, which cause locations of focal curvature [14]. (Right) Current FE simulations showing our ability to simulate permanent set effects. Note that these effects are not due to loading but rather scission/rebonding (healing) of the cross-linked matrix.




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