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Design Innovation Paper

Design of Novel Mixer and Applicator for Two-Component Surgical Adhesives

[+] Author and Article Information
Kevin Go

Department of Biomedical Engineering,
McCormick School of Engineering and Applied Science,
Northwestern University,
2145 Sheridan Road,
Evanston, IL 60208
e-mail: KevinGo2014@u.northwestern.edu

Yeong Kim

Department of Biomedical Engineering,
McCormick School of Engineering and Applied Science,
Northwestern University,
2145 Sheridan Road,
Evanston, IL 60208
e-mail: YeongKim2011@u.northwestern.edu

Andy H. Lee

Department of Biomedical Engineering,
McCormick School of Engineering and Applied Science,
Northwestern University,
2145 Sheridan Road,
Evanston, IL 60208
e-mail: AndyLee2015@u.northwestern.edu

Kelly Staricha

Department of Biomedical Engineering,
McCormick School of Engineering and Applied Science,
Northwestern University,
2145 Sheridan Road,
Evanston, IL 60208
e-mail: Kelly@northwestern.edu

Phillip Messersmith

Department of Biomedical Engineering,
McCormick School of Engineering and Applied Science,
Northwestern University,
2145 Sheridan Road,
Evanston, IL 60208
e-mail: PhilM@berkeley.edu

Matthew Glucksberg

Department of Biomedical Engineering,
McCormick School of Engineering and Applied Science,
Northwestern University,
2145 Sheridan Road,
Evanston, IL 60208
e-mail: M-Glucksberg@northwestern.edu

1Kevin Go, Yeong Kim, Andy H. Lee, and Kelly Staricha contributed equally to this work.

2Corresponding author.

Manuscript received January 29, 2015; final manuscript received June 3, 2015; published online August 6, 2015. Assoc. Editor: Rita M. Patterson.

J. Med. Devices 9(4), 045001 (Aug 06, 2015) (6 pages) Paper No: MED-15-1019; doi: 10.1115/1.4030828 History: Received January 29, 2015

Current mixer and applicator devices on the market are not able to properly and efficiently mix two-component surgical adhesives in small volumes necessary to achieve economic viability. Furthermore, in these devices a significant amount of adhesive is wasted during the application process, as material within the dead space of the mixing chamber must be discarded. We have designed and demonstrated a new active mixer and applicator system capable of rapidly and efficiently mixing two components of an adhesive and applying it to the surgical site. Recently, Messersmith et al. have developed a tissue adhesive inspired by the mussel byssus and have shown that it is effective as a surgical sealant, and is especially suited for wet environments such as in fetal surgery. Like some other tissue sealants, this one requires that two components of differing viscosities be thoroughly mixed within a specified and short time period. Through a combination of compression and shear testing, we demonstrated that our device could effectively mix the adhesive developed by Messersmith et al. and improve its shear strength to significantly higher values than what has been reported for vortex mixing. Overall, our mixer and applicator system not only has potential applications in mixing and applying various adhesives in multiple surgical fields but also makes this particular adhesive viable for clinical use.

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Figures

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Fig. 1

Schematic of design concept. Steps: (1) Injection of activator component into polymer, (2) Eppendorf tube containing mixture rotates relative to needle, and (3) mixed adhesive is pulled up into syringe and is ready for application.

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Fig. 4

Formed adhesive gel for compression testing

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Fig. 3

Circuit diagram of electromechanical components

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Fig. 2

(a) Top view of device and (b) side view of device

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Fig. 5

Comparison of maximum compression stress between vortex mixing (control), device mixing with 0 deg tilt angle, and device mixing with 10 deg tilt angle. Values are (mean±SD).

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Fig. 6

Comparison of maximum shear stress between vortex mixing (control) and device mixing with 10 deg tilt angle. Values are (mean±SD).

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