Special Section Technical Briefs

Design and Development of a Rat Peritoneal Infusion Device for Oxygen Microbubble Bolus Delivery1

[+] Author and Article Information
Liana Hatoum, Nathan Legband, Benjamin Terry

Department of Mechanical and Material Engineering,
University of Nebraska-Lincoln,
Lincoln, NE 68588

Alec Thomas, Mark Borden

Department of Mechanical Engineering,
University of Colorado-Boulder,
Boulder, CO 80302

Craig Kreikemeier-Bower

Institutional Animal Care Program,
University of Nebraska-Lincoln,
Lincoln, NE 68583

Douglas Hostetler

School of Veterinary Medicine and Biomedical Sciences,
University of Nebraska-Lincoln,
Lincoln, NE 68583

Keely Buesing

Department of Surgery,
University of Nebraska Medical Center,
Omaha, NE 68198

DOI: 10.1115/1.4033203Manuscript received March 1, 2016; final manuscript received March 17, 2016; published online May 12, 2016. Editor: William Durfee.

J. Med. Devices 10(2), 020908 (May 12, 2016) (2 pages) Paper No: MED-16-1152; doi: 10.1115/1.4033203 History: Received March 01, 2016; Revised March 17, 2016

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Chiu, L.-C. , Tsai, F.-C. , Hu, H.-C. , Chang, C.-H. , Hung, C.-Y. , Lee, C.-S. , Li, S.-H. , Lin, S.-W. , Li, L.-F. , Huang, C.-C. , Chen, N.-H. , Yang, C.-T. , Chen, Y.-C. , and Kao, K.-C. , 2015, “ Survival Predictors in Acute Respiratory Distress Syndrome With Extracorporeal Membrane Oxygenation,” Ann. Thorac. Surg., 99(1), pp. 243–250. [CrossRef] [PubMed]
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Legband, N. D. , Feshitan, J. A. , Borden, M. A. , and Terry, B. S. , 2015, “ Evaluation of Peritoneal Microbubble Oxygenation Therapy in a Rabbit Model of Hypoxemia,” IEEE Trans. Biomed. Eng., 62(5), pp. 1376–1382. [CrossRef] [PubMed]
Legband, N. , Buesing, K. , Borden, M. , and Terry, B. , 2015, “ The Treatment of Acute Respiratory Distress Syndrome in Rats With a Peritoneal Dosing System,” ASME J. Med. Devices, 9(2), p. 020929.
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Grahic Jump Location
Fig. 2

Concentrations of gases in OMBs before and after injection

Grahic Jump Location
Fig. 1

Schematic of OMB BIS for a rat



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