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Special Section Technical Briefs

Tissue Necrosis Associated With Chemical Ablations1

[+] Author and Article Information
Ashish Singal

Department of Biomedical Engineering,
Surgery, Cardiovascular Medicine,
University of Minnesota,
Minneapolis, MN 55455

Charles L. Soule

Department of Surgery,
University of Minnesota,
Minneapolis, MN 55455

Paul A. Iaizzo

Department of Biomedical Engineering,
Surgery, Integrative Biology and Physiology,
Institute for Engineering in Medicine,
University of Minnesota,
Minneapolis, MN 55455

DOI: 10.1115/1.4033120Manuscript received March 1, 2016; final manuscript received March 16, 2016; published online May 12, 2016. Editor: William Durfee.

J. Med. Devices 10(2), 020925 (May 12, 2016) (3 pages) Paper No: MED-16-1060; doi: 10.1115/1.4033120 History: Received March 01, 2016; Revised March 16, 2016

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Figures

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Fig. 1

Injection of chemical agent; note that the syringe is inserted at an acute angle so that agent is administered near the center of the muscle bundle

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Fig. 2

Top: Swine diaphragm muscle bundles after TTC staining for 3 hrs, where the central pale-white region marks the ablated region; bottom: cross-sectional slices of the same muscle bundles performed to calculate area assessment

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Fig. 3

Ablated area determination using imagej software. On left is swine diaphragm muscle bundles injected with Krebs-buffer solution (controls, no necrosis). In center and right are swine trabeculae muscle bundles injected with 50 μL of ethanol and 50 μL of acetic acid, respectively, showing acetic acid is more potent agent as compared to ethanol.

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Fig. 4

Ablated tissue area following CHA in swine diaphragm muscle bundles with all the agents. Acetic acid had highest ablative potency (p < 0.05) as compared to other three agents where statistical significance was not observed.

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Fig. 5

For the same ablative dose, trabeculae suffered higher tissue necrosis compared to diaphragm

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