Special Section Technical Briefs

Development of a Chronic Wound Healing Device1

[+] Author and Article Information
Vighneswara Siva Santosh Kumar Kondeti, Peter J. Bruggeman

Department of Mechanical Engineering,
University of Minnesota,
Minneapolis, MN 55455

Chi Phan, Ryan C. Hunter

Department of Microbiology and Immunology,
University of Minnesota,
Minneapolis, MN 55455

Alexandria Schauer, Jennifer Granick

Veterinary Clinical Sciences,
University of Minnesota,
Minneapolis, MN 55455

DOI: 10.1115/1.4033240Manuscript received March 1, 2016; final manuscript received March 17, 2016; published online May 12, 2016. Editor: William Durfee.

J. Med. Devices 10(2), 020937 (May 12, 2016) (2 pages) Paper No: MED-16-1168; doi: 10.1115/1.4033240 History: Received March 01, 2016; Revised March 17, 2016

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Isbary, G. , Morfill , H. U., Schmidt , M., Georgi , K., Ramrath , J., Heinlin , S., Karrer , S., Landthaler , M., Shimizu , T., Steffes , B., Bunk , W., Monetti , R., Zimmermann , J. L., Pompl , R., and Stolz, W. , 2010, “ A First Prospective Randomized Controlled Trial to Decrease Bacterial Load Using Cold Atmospheric Argon Plasma on Chronic Wounds in Patients,” Br. J. Dermatol., 163(1), pp. 78–82. [PubMed]
Ermolaeva, S. A. , Varfolomeev, A. F. , Chernukha, M. Y. , Yurov, D. S. , Vasiliev, M. M. , Kaminskaya, A. A. , Moisenovich, M. M. , Romanova, J. M. , Murashev, A. N. , Selezneva, I. I. , Shimizu, T. , Sysolyatina, E. V. , Shaginyan, I. A. , Petrov, O. F. , Mayevsky, E. I. , Fortov, V. E. , Morfill, G. E. , Naroditsky, B. S. , and Gintsburg, A. L. , 2011, “ Bactericidal Effects of Non-Thermal Argon Plasma In Vitro, in Biofilms and in the Animal Model of Infected Wounds,” J. Med. Microbiol., 60(Pt. 1), pp. 75–83. [CrossRef] [PubMed]
Lukes, P. , Dolezalova, E. , Sisrova, I. , and Clupek, M. , 2014, “ Aqueous-Phase Chemistry and Bactericidal Effects From an Air Discharge Plasma in Contact With Water: Evidence or the Formation of Peroxynitrite Through a Pseudo-Second-Order Post-Discharge Reaction of H2O2 and HNO2,” Plasma Sources Sci. Technol., 23(1), p. 015019. [CrossRef]
van Gils, C. A. J. , Hofmann, S. , Boekema, B. K. H. L. , Brandenburg, R. , and Bruggeman, P. J. , 2013, “ Mechanisms of Bacterial Inactivation in the Liquid Phase Induced by a Remote RF Cold Atmospheric Pressure Plasma Jet,” J. Phys. D: Appl. Phys., 46(17), p. 175203. [CrossRef]
van Ham, B. T. J. , Hofmann, S. , Brandenburg, R. , and Bruggeman, P. J. , 2014, “ In Situ Absolute Air, O3 and NO Densities in the Effluent of a Cold RF Argon Atmospheric Pressure Plasma Jet Obtained by Molecular Beam Mass Spectrometry,” J. Phys D: Appl. Phys., 47(22), p. 224013. [CrossRef]
van Gessel, A. F. H. , Alards, K. M. J. , and Bruggeman, P. J. , 2013, “ NO Production in an RF Plasma Jet at Atmospheric Pressure,” J. Phys. D: Appl. Phys., 46(26), p. 265202. [CrossRef]
Wende, K. , Williams, P. , Dalluge, J. , Gaens, W. V. , Aboubakr, H. , Bischof, J. , von Woedtke, T. , Goyal, S. M. , Weltmann, K. D. , Bogaerts, A. , Masur, K. , and Bruggeman, P. J. , 2015, “ Identification of the Biologically Active Liquid Chemistry Induced by a Nonthermal Atmospheric Pressure Plasma Jet,” Biointerphases, 10(2), p. 029518. [CrossRef] [PubMed]


Grahic Jump Location
Fig. 1

Image of the plasma jet

Grahic Jump Location
Fig. 2

Inactivation of PA planktonic in 0.9% saline (top) and in PBS (bottom)

Grahic Jump Location
Fig. 3

Inactivation of SA + PA bacteria in biofilms. Untreated biofilm (left) and plasma-treated biofilm (right).



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