Technical Brief

A Low-Cost, Fully Programmable, Battery Powered Direct Cortical Electrical Stimulator1

[+] Author and Article Information
Po T. Wang

Biomedical Engineering,
University of California–Irvine (UCI),
Irvine, CA 92697

Alireza Karimi-Bidhendi, Payam Heydari

Electrical Engineering and Computer Science,
University of California–Irvine (UCI),
Irvine, CA 92697

Charles Y. Liu

Neurorestoration Center,
University of Southern California,
Los Angeles, CA 90033

Zoran Nenadic

Biomedical Engineering,
University of California–Irvine (UCI),
Irvine, CA 92697;
Electrical Engineering and Computer Science,
University of California–Irvine (UCI),
Irvine, CA 92697

An H. Do

University of California–Irvine (UCI),
Irvine, CA 92697

DOI: 10.1115/1.4033732Manuscript received March 1, 2016; final manuscript received March 21, 2016; published online August 1, 2016. Editor: William Durfee.

J. Med. Devices 10(3), 030901 (Aug 01, 2016) (3 pages) Paper No: MED-16-1074; doi: 10.1115/1.4033732 History: Received March 01, 2016; Revised March 21, 2016

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O'Doherty, J. E. , Lebedev, M. , Li, Z. , and Nicolelis, M. A. , 2012, “ Virtual Active Touch Using Randomly Patterned Intracortical Microstimulation,” IEEE Trans. Neural Syst. Rehabil. Eng., 20(1), pp. 85–93. [CrossRef] [PubMed]
Kolbl, F. , N'Kaoua, G. , Naudet, F. , Berthier, F. , Faggiani, E. , Renaud, S. , Benazzouz, A. , and Lewis, N. , 2016, “ An Embedded Deep Brain Stimulator for Biphasic Chronic Experiments in Freely Moving Rodents,” IEEE Trans. Biomed. Circuits Syst., 10(1), pp. 72–84. [CrossRef] [PubMed]
Sillay, K. A. , Rutecki, P. , Cicora, K. , Worrell, G. , Drazkowski, J. , Shih, J. J. , Sharan, A. D. , Morrell, M. J. , Williams, J. , and Wingeier, B. , 2013, “ Long-Term Measurement of Impedance in Chronically Implanted Depth and Subdural Electrodes During Responsive Neurostimulation in Humans,” Brain Stimul., 6(5), pp. 718–726. [CrossRef] [PubMed]


Grahic Jump Location
Fig. 3

Maximum current output (A) at varying stimulation frequencies (pulse width fixed at 500 μs) and pulse widths (frequency fixed at 300 Hz). Dashed lines indicate the 20 mA threshold.

Grahic Jump Location
Fig. 2

Top: Representative square-pulse wave (screenshot from the oscilloscope). Bottom: Current amplitude based on digital potentiometer steps for each load.

Grahic Jump Location
Fig. 1

Circuit diagram of the cortical stimulator



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