Technical Brief

Design of a Steerable Guide for Laser Interstitial Thermal Therapy of Brain Tumors1

[+] Author and Article Information
Mahmood Rezapour

Department of Mechanical Engineering,
Southern Illinois University–Edwardsville,
Edwardsville, IL 62026

Eric C. Leuthardt

Department of Neurological Surgery,
Washington University in St. Louis,
St. Louis, MO 63130;
Department of Biomedical Engineering,
Washington University in St. Louis,
St. Louis, MO 63130;
Department of Mechanical Engineering and
Materials Science,
Washington University in St. Louis,
St. Louis, MO 63130

Jenna L. Gorlewicz

Department of Aerospace and Mechanical Engineering,
Saint Louis University,
Saint Louis, MO 63103

DOI: 10.1115/1.4033786Manuscript received March 1, 2016; final manuscript received March 17, 2016; published online August 1, 2016. Editor: William Durfee.

J. Med. Devices 10(3), 030909 (Aug 01, 2016) (2 pages) Paper No: MED-16-1104; doi: 10.1115/1.4033786 History: Received March 01, 2016; Revised March 17, 2016

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Prados, M. , 2000, “ Neoplasms of the Central Nervous System,” Cancer Medicine, 5th ed., R. Bast , D. Kufe , R. Pollock , R. Weichselbaum , J. Holland , and E. Frei , eds., B. C. Decker, Hamilton, ON, Canada, pp. 1055–1082.
Hawasli, A. H. , Ray, W. Z. , Murphy, R. K. , Dacey, R. G., Jr. , and Leuthardt, E. C. , 2012, “ Magnetic Resonance Imaging-Guided Focused Laser Interstitial Thermal Therapy for Subinsular Metastatic Adenocarcinoma: Technical Case Report,” Neurosurgery, 70(2 Suppl.), pp. E332–E338.
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Grahic Jump Location
Fig. 1

The NeuroBlate® System by the Monteris Medical, Inc., which enables minimally invasive access for neurosurgical ablation under MRI-guidance. Figures obtained from the Monteris Medical, Inc.

Grahic Jump Location
Fig. 2

A side view and cross section view of our steerable guide integrated with the NeuroBlate® laser system. Our guide consists of (1) a 3.3 mm outer straight tube, (2) a 2.8 mm inner plastic tube, and (5) a 0.8 mm Nitinol guidewire backbone. The existing NeuroBlate® laser system consists of (3) the laser cooling tube, (4) a thermocouple, (6) a probe tip holder, (7) the fiber-optic laser, (8) the laser tip, and (9) a powder filler.

Grahic Jump Location
Fig. 3

Our steerable guide integrated within the existing Neuroblate® System



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