Technical Brief

Computer-Controlled Eucapnic Voluntary Hyperpnea Challenge Method

[+] Author and Article Information
Ahmed M. Al-Jumaily

Fellow ASME
Institute of Biomedical Technologies (IBTec),
Auckland University of Technology,
Private Bag 92006,
Auckland 1142, New Zealand
e-mail: ahmed.al-jumaily@aut.ac.nz

Lulu Wang

School of Instrument Science
and Optoelectronics Engineering,
Hefei University of Technology,
193 Tunxi Road,
Hefei 230009, China
e-mail: luluwang2015@hfut.edu.cn

Manuscript received October 22, 2015; final manuscript received May 31, 2016; published online September 12, 2016. Assoc. Editor: Xiaoming He.

J. Med. Devices 10(4), 044507 (Sep 12, 2016) (5 pages) Paper No: MED-15-1282; doi: 10.1115/1.4034146 History: Received October 22, 2015; Revised May 31, 2016

Eucapnic voluntary hyperpnea (EVH) challenge is a well-established and sensitive method of determining the degree of bronchoconstriction at hospitals and clinics. This paper presents the development of a computer-controlled system for assessing exercise-induced bronchoconstriction (EIB) in humans including a computer graphic user interface (GUI) to control a low-pressure demand valve for better efficiency. GUI is designed to monitor the severity of acute lung airway narrowing using a matlab software and to present the measurement data into a simple user-friendly program consisting of patient information, EVH test analysis, and detection of exercise-induced asthma (EIA) and EIB. The proposed system is assessed using human subjects. Typical outputs from this system showed that for a female participant, a 20.25% and a 15.61% decrease from baseline in her forced expiratory volume in 1 s (FEVl) after 10 and 15 min of the challenge commencement, respectively. Her actual expiratory flow rate (45.833 L/m) and actual total volume of gas respired (275 L) were smaller than the target values. This system widens the usage of EVH challenge in medical areas, and the GUI may serve as a new clinical computer-aided diagnostic tool to help healthcare professionals noninvasively monitor the severity of asthma, EIA, and EIB.

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Grahic Jump Location
Fig. 1

(a) Overview of the proposed EVH system (computer and spirometer are not shown)—1: mouthpiece; 2: LPRR; 3: low-pressure hose; 4: HPRR; 5: high-pressure hose; 6: dive computer to work as digital pressure gauge; and 7: gas cylinder with compressed gas. (b) Overview of HPRR—b1: main body; b2: inlet port; b3: cylinder fitting; b4: outlet port to LPRR; and b5: outlet port to pressure gauge. (c) Inside view of HPRR—c1: intermediate pressure seat; c2: intermediate pressure spring; c3: O-ring; c4: inlet port; c5: high-pressure spring; c6: high-pressure seat; c7: high-pressure valve; c8 and c9: high-pressure chamber; c10: intermediate pressure chamber; c11: intermediate pressure valve; and c12: diaphragm. (d) Inside view of LRPP—d1: seat; d2: mouthpiece; d3 and d12: cracking resistance control; d4: intermediate portion; d5: demand lever; d6: gas from HPRR; d7: diaphragm; d8: rubber seating; d9: coil spring; d10: poppet valve; d11: tubular housing; d13: knob; and d14: ambient pressure.

Grahic Jump Location
Fig. 2

Snapshot of patient information screen

Grahic Jump Location
Fig. 3

EVH challenge result



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