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Research Papers

A New Concept of Needle-Free Jet Injector by the Impact Driven Method

[+] Author and Article Information
Prachya Mukda

Faculty of Engineering,
Department of Mechanical Engineering,
Ubon Ratchathani University,
85 Sathonlamark Road, Warinchamrap,
Ubon Ratchathani 34190, Thailand
e-mail: mukdaen@hotmail.com

Kulachate Pianthong

Faculty of Engineering,
Department of Mechanical Engineering,
Ubon Ratchathani University,
85 Sathonlamark Road, Warinchamrap,
Ubon Ratchathani 34190, Thailand
e-mail: Kulachate.p@ubu.ac.th

Wirapan Seehanam

Faculty of Engineering,
Department of Mechanical Engineering,
Ubon Ratchathani University,
85 Sathonlamark Road, Warinchamrap,
Ubon Ratchathani 34190, Thailand
e-mail: wirapan.s@ubu.ac.th

1Corresponding author.

Manuscript received January 30, 2016; final manuscript received December 19, 2016; published online January 25, 2017. Assoc. Editor: Matthew Myers.

J. Med. Devices 11(1), 011011 (Jan 25, 2017) (10 pages) Paper No: MED-16-1013; doi: 10.1115/1.4035563 History: Received January 30, 2016; Revised December 19, 2016

Currently, most of commercial needle-free jet injectors generate the liquid jet by a method called “driving object method” (DOM); however, the reliability and efficiency are still questioned. This paper proposes a new concept of jet generation method, known as “impact driven method” (IDM). A prototype of an IDM jet injector is designed, built, tested, and compared to a commercial device (Cool.click, Tigard, OR). Fundamental characteristics, i.e., the exit jet velocity and impact pressure, are measured. Jet injection processes are visualized both in air and in 20% polyacrylamide by high speed photography. In this study, from the prototype of the IDM jet injector, a maximum jet velocity of 400 m/s and impact peak pressure of 68 MPa can be obtained. It is clear that the IDM jet injector provides a double pulsed liquid jet, which is a major advantage over the commercial jet injector. Because, the first pulse gives a shorter erosion stage, and then, immediately the second pulse follows and provides a better penetration, wider lateral dispersion, and considerably less back splash. Hence, lower pain level and higher delivery efficiency should be achieved. It can be concluded that the IDM concept is highly feasible for implementation in real applications, either for human or animal injection. However, the control and accuracy of IDM still needs to be carefully investigated.

Copyright © 2017 by ASME
Topics: Pressure , Ejectors , Jets , needles
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References

Figures

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Fig. 5

IDM jet injector system

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Fig. 4

Pressure contours (GPa) inside a conical nozzle caused by IDM [23]

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Fig. 3

Multiple pulsed liquid jets generated by IDM [21]

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Fig. 2

Impact driven method (IDM) for high speed liquid jet generation: (a) direct impact method (DIM) and (b) momentum exchange method (MEM)

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Fig. 1

Drug delivery to the skin as a function of impact peak pressure

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Fig. 6

Details of jet injectors: (a) IDM jet injector and (b) DOM Cool.click

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Fig. 7

Arrangement of jet velocity measurement

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Fig. 10

Calibration curve of the impact pressure of the PVDF piezoelectric film

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Fig. 8

PVDF film response method

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Fig. 9

Configuration of the PVDF calibration setup and data acquisition system

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Fig. 17

Top view area after injection: (a) IDM jet injector and (b) Cool.click

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Fig. 14

Visualization of the IDM jet by a high speed camera: (a) the first pulse, (b) the second pulse, and (c)–(h) later stage of the injection

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Fig. 15

Delivery process from the IDM jet injector

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Fig. 11

(a) IDM jet injector, (b) Cool.click, and (c) the visualization setup for determining the penetration mechanism

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Fig. 16

Delivery process of the DOM jet from Cool.click

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Fig. 12

Characteristics of IDM liquid jets versus reservoir pressure: (a) exit jet velocity and impact peak pressure and (b) jet power

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Fig. 13

Details of the first 4 ms of the impact pressure versus time response from the PVDF film response method

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