Prior studies have linked microbial contamination of intravenous (IV) ports and stopcocks with post-operative infections. Existing technologies to prevent contamination are not consistently utilized because of the time and effort they require. Herein, novel barrier devices were created that form a protective shell to passively prevent contact between injection sites and practitioner hands or environmental surfaces while still allowing rapid connection of a syringe for injection of medications via an opening in the shell. Prototypes were tested using a grossly contaminated environment and ATP-bioluminescence assay. For 8 pairs of unshielded vs. shielded IV ports/stopcocks, average contamination was 4,102 vs. 35 RLU (p<0.02), respectively, indicating that the devices could significantly reduce IV port/stopcock contamination.