A numerical analysis of a semi-enclosed tubular Mechanical Embolus Retrieval Device (MERD) for the treatment of Acute Ischemic Stroke (AIS) is presented. In this research, the FEA (Finite Element Analysis) methodology is used to evaluate mechanical performance and provide suggestions for optimizing the geometric design. A MERD fabricated from nickel-titanium alloy (Nitinol) tubing is simulated and analyzed under complex in-vivo loading conditions involving shape-setting, crimping, deployment, and embolus retrieval. As a result, the peak strain of the shape-setting procedure is proved to be safe for the device pattern. However, the MERD shows poor mechanical behavior after crimping into a catheter, because the peak crimping strain obtains a value of 12.1%. The delivery and deployment step demonstrates that the artery wall has little risk of serious injuries or ruptures. In addition, the process of simulation of embolus retrieval and device system migration inside the cerebral artery lumen provides useful information during the design process.