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Design Innovation Paper

Development of an alveolar transbronchial catheter for concurrent fiber optics based imaging and fluid delivery

[+] Author and Article Information
Nathan Knighton

Department of Bioengineering, University of Utah, 36 S Wasatch Dr., Salt Lake City UT, 84112
nate.knighton@utah.edu

Brian Cottle

Department of Bioengineering, University of Utah, 36 S Wasatch Dr., Salt Lake City UT, 84112
brian.k.cottle@utah.edu

Veronique Dentan

Mauna Kea Technologies, 9, rue d’Enghien, Paris, 75010, France
veronique@maunakeatech.com

Tom Vercauteren

University College London, Wellcome / EPSRC Centre for Interventional and Surgical Sciences, Charles Bell House, 43-45 Foley Street, London W1W 7TS, United Kingdom
t.vercauteren@ucl.ac.uk

Ahsan Akram

EPSRC Proteus Hub, MRC Centre for Inflammation Research, The University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
ahsan.akram@ed.ac.uk

Annya Bruce

EPSRC Proteus Hub, MRC Centre for Inflammation Research, The University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
annya.bruce@ed.ac.uk

Kevin Dhaliwal

EPSRC Proteus Hub, MRC Centre for Inflammation Research, The University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
kev.dhaliwal@ed.ac.uk

Robert Hitchcock

Department of Bioengineering, University of Utah, 36 S Wasatch Dr., Salt Lake City UT, 84112
r.hitchcock@utah.edu

1Corresponding author.

ASME doi:10.1115/1.4040639 History: Received March 16, 2018; Revised June 18, 2018

Abstract

Optical molecular imaging is an emerging field and high resolution optical imaging of the distal lung parenchyma has been made possible with the advent of clinically approved fiber based imaging modalities. However, currently, there is no single method of allowing the simultaneous imaging and delivery of targeted molecular imaging agents. We describe the rationale, development, and validation to near clinical readiness of a triple lumen bronchoscopy catheter that allows concurrent imaging and fluid delivery, with the aim of clinical use to deliver multiple fluorescent compounds to image alveolar pathology.

Copyright (c) 2018 by ASME
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